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Merck
CN

719897

Sigma-Aldrich

RESOMER® RG 502 H，聚（d，L-丙交酯-共-乙交酯）

acid terminated, viscosity 0.16-0.24 dL/g 

别名:

PLGA, RESOMER® RG 502 H

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关于此项目

线性分子式:
[C3H4O2]x[C2H2O2]y
化学文摘社编号:
26780-50-7
MDL编号:
MFCD00131930
UNSPSC代码:
12162002
NACRES:
NA.23

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质量水平

200

表单

amorphous

投料比

lactide:glycolide 50:50

降解时间线

<3 months

粘度

0.16-0.24 dL/g

转变温度

Tg 42-46 °C

储存温度

2-8°C

SMILES字符串

O2C(C(=O)OC(C2=O)C)C.O1CC(=O)OCC1=O

InChI

1S/C6H8O4.C4H4O4/c1-3-5(7)10-4(2)6(8)9-3;5-3-1-7-4(6)2-8-3/h3-4H,1-2H3;1-2H2

InChI key

LCSKNASZPVZHEG-UHFFFAOYSA-N

相关类别

应用

聚（(D,L-丙交酯-co-乙交酯）（PLGA）可用于：

  • 为H2S供体配制非水药物递送系统，以促进药物的持续释放。
  • 制备含有分散于 PLGA–PEG–PLGA聚合物凝胶中的更昔洛韦微球的聚合物混合物。该制剂可用作更昔洛韦药物的持续给药系统。
它也可用于制造释放一氧化氮的葡萄糖和乳酸传感器。

法律信息

Evonik产品
RESOMER is a registered trademark of Evonik Rohm GmbH

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCX7331
MKCX2944
MKCX2102
MKCV8978
BCCH1660

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A Patil et al.
AAPS PharmSciTech, 18(6), 2291-2302 (2017-01-20)
Hydrogen sulfide (H2S) targets both underlying factors in glaucoma pathogenesis by reducing elevated intraocular pressure (IOP) and providing retinal neuroprotection, whereas the current clinical approaches targets only reducing IOP. Therefore, H2S could be a potential superior candidate for glaucoma pharmacotherapy.
Sridhar Duvvuri et al.
Journal of controlled release : official journal of the Controlled Release Society, 108(2-3), 282-293 (2005-10-19)
The purpose of this work is to develop empirical equations for describing the in vitro ganciclovir (GCV) release from PLGA microspheres and also to develop and characterize a formulation containing GCV loaded PLGA microspheres dispersed in thermogelling PLGA-PEG-PLGA polymer gel.
Qinyi Yan et al.
Biosensors & bioelectronics, 26(11), 4276-4282 (2011-05-20)
Intravenous amperometric needle-type enzymatic glucose/lactate sensors intended for continuous monitoring are prepared with a novel nitric oxide (NO) releasing layer to improve device hemocompatibility. To create an underlying NO release coating, the sensors with immobilized enzymes (either glucose oxidase or
Diazeniumdiolate-doped poly (lactic-co-glycolic acid)-based nitric oxide releasing films as antibiofilm coatings.
Cai W,et al.
Biomaterials, 33(32), 7933-7944 (2012)
Z Zhuang et al.
Journal of dental research, 98(2), 200-208 (2018-11-06)
Periodontitis is characterized by the progressive destruction of tooth-supporting alveolar bone, which is mainly caused by chronic inflammation in response to persistent bacterial insult. It has recently become clear that the pathogenesis of periodontitis is associated with a high ratio
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商品

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Synthetic aliphatic polyesters dominate resorbable biomaterials in clinical use.

Biodegradable Polyester Nanoparticle Formation

AliAliphatic polyesters, including polylactide and polyglycolide, are biodegradable polymers widely used in medical applications.

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