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Merck
CN

719900

Resomer® RG 504 H,聚(D,L-丙交酯-co-乙交酯)

acid terminated, lactide:glycolide 50:50, Mw 38,000-54,000

别名:

RESOMER® RG 504 H, PLGA

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关于此项目

线性分子式:
[C3H4O2]x[C2H2O2]y
化学文摘社编号:
MDL number:
UNSPSC Code:
12162002
NACRES:
NA.23
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SMILES string

O2C(C(=O)OC(C2=O)C)C.O1CC(=O)OCC1=O

InChI

1S/C6H8O4.C4H4O4/c1-3-5(7)10-4(2)6(8)9-3;5-3-1-7-4(6)2-8-3/h3-4H,1-2H3;1-2H2

InChI key

LCSKNASZPVZHEG-UHFFFAOYSA-N

form

amorphous

feed ratio

lactide:glycolide 50:50

mol wt

Mw 38,000-54,000

degradation timeframe

<3 months

viscosity

0.45-0.60 dL/g, 0.1 % (w/v) in chloroform(25 °C, Ubbelohde) (size 0c glass capillary viscometer)

transition temp

Tg 46-50 °C

storage temp.

2-8°C

Quality Level

Application

Resomer® RG 504 H, 聚(D, L-丙交酯-co-乙交酯)可用于制造一种可生物降解的 止血装置,用于安全和局部控制释放凝血酶, 促进局部血栓形成。

它也可用于制备:包封氧化铜的聚合物纳米球,形成刺激响应的多功能纳米载体。

Legal Information

Evonik产品
RESOMER is a registered trademark of Evonik Rohm GmbH

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


历史批次信息供参考:

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An in situ forming gel (ISFG) of buprenorphine (BP) was prepared using PLGA-PEG-PLGA (triblock) and N‑methyl‑2‑pyrrolidone as solvent for decreasing the initial burst release. Supercritical CO2 method was used for ring opening polymerization of triblock. The optimum formulation of ISFG
Teresa Musumeci et al.
International journal of pharmaceutics, 440(2), 135-140 (2012-10-20)
Melatonin, a neurohormone secreted by the pineal gland, is able to modulate intraocular pressure (IOP). The aim of this study was to generate nanoparticle (NPs) sustained release formulations that allow to extend the pre-corneal residence time of melatonin, thus prolonging
Igor Jeroukhimov et al.
Journal of the American College of Surgeons, 218(1), 102-107 (2013-11-12)
Chronic pain after inguinal hernia repair occurs in 16% to 62% of patients. The underlying mechanism probably involves sensory nerve damage and abnormal healing that might be influenced by the materials chosen for the procedure. We hypothesize that nonabsorbable sutures
Maria Kirzhner et al.
Ophthalmology, 120(6), 1300-1304 (2013-02-13)
To compare wrapped and polymer-coated hydroxyapatite implants in children undergoing primary enucleation with no adjuvant therapies. Retrospective, interventional cohort study. All children undergoing primary enucleation without adjuvant therapies between 1999 and 2009 at a tertiary pediatric cancer hospital. Review and

商品

In the past two decades, tissue engineering and regenerative medicine have become important interdisciplinary fields that span biology, chemistry, engineering, and medicine.

Innovations in polymer technology have had a significant impact on the advancement of novel drug delivery systems.

AliAliphatic polyesters, including polylactide and polyglycolide, are biodegradable polymers widely used in medical applications.

Interest in utilizing biodegradable polymers for biomedical applications has grown since the 1960s.

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