764701
2,5-5-二氧-1-吡咯烷基 5-[4-（1,2,4,5-四嗪-3-基）苄基氨基] -5-氧戊酸
≥90%
别名:
5-Oxo-5-[[[4-(1,2,4,5-tetrazin-3-yl)phenyl]methyl]amino]pentanoic acid 2,5-dioxo-1-pyrrolidinyl ester, Benzylamino tetrazine N-hydroxysuccinimidyl ester, Benzylaminotetrazine-NHS, Bz-Tz-NHS
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关于此项目
经验公式（希尔记法）:
C18H18N6O5
化学文摘社编号:
分子量:
398.37
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.22
Assay:
≥90%
Form:
solid
assay
≥90%
form
solid
reaction suitability
reaction type: click chemistry, reagent type: linker
functional group
NHS ester
storage temp.
−20°C
SMILES string
O=C(CCCC(ON1C(CCC1=O)=O)=O)NCC(C=C2)=CC=C2C3=NN=CN=N3
InChI
1S/C18H18N6O5/c25-14(2-1-3-17(28)29-24-15(26)8-9-16(24)27)19-10-12-4-6-13(7-5-12)18-22-20-11-21-23-18/h4-7,11H,1-3,8-10H2,(H,19,25)
InChI key
QDUUJWMNSUXICN-UHFFFAOYSA-N
Application
2,5-Dioxo-1-pyrrolidinyl 5-[4-(1,2,4,5-tetrazin-3-yl)benzylamino]-5-oxopentanoate may be used in the synthesis of Tz-PEG11-1,4,7-triazacyclononane-N,N,N-triacetate, a precursor for Al[18F]-NOTA-labeled tetrazine radio ligand useful in 18F-based pretargeted PET imaging system.
Succinimidyl ester functionalized tetrazine for inverse electron demand Diels-Alder cycloaddition reactions. Succinimidyl ester will react with amines for small molecule, biomolecule or surface modification. Tetrazine will react with strained alkenes such as transcyclooctene, norbornene and cyclopropene to yield a stable covalent linkage. Tetrazines have proven useful in bioorthogonal reactions for many biological imaging and bioconjugation applications.
Rosemery Membreno et al.
Journal of visualized experiments : JoVE, (143) (2019-02-19)
While radioimmunotherapy (RIT) is a promising approach for the treatment of cancer, the long pharmacokinetic half-life of radiolabeled antibodies can result in high radiation doses to healthy tissues. Perhaps not surprisingly, several different strategies have been developed to circumvent this
Specific Binding of Liposomal Nanoparticles through Inverse Electron?Demand Diels?Alder Click Chemistry.
Brand C, et al.
ChemistryOpen null
18F-Based Pretargeted PET Imaging Based on Bioorthogonal Diels?Alder Click Chemistry
Meyer JP, et al.
Bioconjugate Chemistry, 27(2), 298-301 (2015)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 764701-5MG | 04061833231067 |
| 764701-25MG | 04061833231050 |
| 764701-1MG | 04061826701652 |