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Merck
CN

764787

Poly(lactide-co-glycolide)-block-poly(ethylene glycol)-block-poly(lactide-co-glycolide)

average Mn (1,000-1,000-1,000), lactide:glycolide 50:50

别名:

PLGA-PEG-PLGA

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关于此项目

NACRES:
NA.23
UNSPSC Code:
12162002

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description

typical PEG PDI<1.1; overall PDI<1.2 (THF, PEO)

form

liquid

feed ratio

lactide:glycolide 50:50

mol wt

PEG average Mn 1,000, PLGA average Mn 2000, average Mn (1,000-1,000-1,000)

degradation timeframe

1-2 weeks

PDI

<1.2

storage temp.

2-8°C

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Application

Used in the synthesis of targeted nanoparticles which are used for differential delivery and controlled release of drugs.

Features and Benefits

Biocompatible, degradable, thermosensitive, high stability, small size (<200 nm) and properties can be easily modified.

General description

PLGA-PEG-PLGA is an amphiphilic triblock copolymer which can self-assemble into micelles in aqueous medium due to the hydrophobic interactions present in the hydrophobic segments. The PEG segment imparts hydrophilicity and improves the biocompatibility of the copolymer. The PLGA segment forms a hydrophobic core and can solubilize hydrophobic drugs. These copolymers are widely used as nanocarriers for the sustained release of drugs.

存储类别

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCN7068
MKCG6095
MKCC8982
MKBX1132V
MKBT6439V

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Zhimei Song et al.
Journal of colloid and interface science, 354(1), 116-123 (2010-11-04)
The aim of this study was to assess the potential of new copolymeric micelles to modify the pharmacokenetics and tissue distribution of Curcumin (CUR), a hydrophobic drug. In the present study, a poly (d,l-lactide-co-glycolide)-b-poly(ethylene glycol)-b-poly(d,l-lactide-co-glycolide) (PLGA-PEG-PLGA) copolymer was synthesized and
PLGA-PEG Encapsulated sitamaquine nanoparticles drug delivery system against Leishmania donovani
Kumara, R., Sahoo, G. C., Pandeya, K., Dasa, V. N. R., Yousuf, M., Ansaria, S. R., &amp; Dasa, P.
Journal of Scientific and Innovative Research, 3(1), 85-90 (2014)
Frank Gu et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(7), 2586-2591 (2008-02-15)
There has been progressively heightened interest in the development of targeted nanoparticles (NPs) for differential delivery and controlled release of drugs. Despite nearly three decades of research, approaches to reproducibly formulate targeted NPs with the optimal biophysicochemical properties have remained

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