Poly(lactide-co-glycolide)-block-poly(ethylene glycol)-block-poly(lactide-co-glycolide)

PLGA-PEG-PLGA is an amphiphilic triblock copolymer which can self-assemble into micelles in aqueous medium due to the hydrophobic interactions present in the hydrophobic segments. The PEG segment imparts hydrophilicity and improves the biocompatibility of the copolymer. The PLGA segment forms a hydrophobic core and can solubilize hydrophobic drugs. These copolymers are widely used as nanocarriers for the sustained release of drugs.[1]

Used in the synthesis of targeted nanoparticles which are used for differential delivery and controlled release of drugs.[2][3]

Biocompatible, degradable, thermosensitive, high stability, small size (<200 nm) and properties can be easily modified.[1]