form
solid
Quality Level
feed ratio
lactide:glycolide 50:50
mol wt
PEG average Mn 5,000, PLGA Mn 7,000, average Mn 12,000 (total)
degradation timeframe
1-4 weeks
transition temp
Tg 24 °C, Tm 38-43 °C
PDI
<2.0
storage temp.
2-8°C
General description
两亲性嵌段共聚物（AmBC）由两种化学上不同的均聚物嵌段组成。嵌段之一是亲水的，另一个是疏水的。这些大分子溶于水介质时具有自组装的特性。PEG-PLGA是最常用于药物递送应用的可生物降解的两亲嵌段共聚物之一。PEG是亲水部分，PLGA是疏水部分。
Application
可用于合成靶向纳米粒子，从而用于差异递送和控释药物。
形成“隐形”聚乙二醇化微粒
Features and Benefits
- 良好的生物相容性、低免疫原性和良好的降解性。
- 通过改变嵌段共聚物链段的尺寸可以轻松调节其性能，以适合特定应用。
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
No data available
flash_point_c
No data available
商品
Local delivery of bioactive molecules using an implantable device can decrease the amount of drug dose required as well as non-target site toxicities compared to oral or systemic drug administration.
AliAliphatic polyesters, including polylactide and polyglycolide, are biodegradable polymers widely used in medical applications.
The development of drugs that target specific locations within the human body remains one of the greatest challenges in biomedicine today.
Thermosensitive self-assembling block copolymers as drug delivery systems.
Bonacucina, G., Cespi, M., Mencarelli, G., Giorgioni, G., & Palmieri, G. F.
Polymer, 3(2), 779-811 (2011)
PLGA-PEG Encapsulated sitamaquine nanoparticles drug delivery system against Leishmania donovani
Kumara, R., Sahoo, G. C., Pandeya, K., Dasa, V. N. R., Yousuf, M., Ansaria, S. R., & Dasa, P.
Journal of Scientific and Innovative Research, 3(1), 85-90 (2014)
Frank Gu et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(7), 2586-2591 (2008-02-15)
There has been progressively heightened interest in the development of targeted nanoparticles (NPs) for differential delivery and controlled release of drugs. Despite nearly three decades of research, approaches to reproducibly formulate targeted NPs with the optimal biophysicochemical properties have remained
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 76575-5ML | 04061837583261 |
| 76575-25ML | 04061837583254 |
| 765139-1G | 04061832923307 |