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文件

779431

Sigma-Aldrich

γ-环糊精

produced by Wacker Chemie AG, Burghausen, Germany, ≥90.0% cyclodextrin basis (HPLC)

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别名:
Schardinger γ-Dextrin, 环八淀粉, 环麦芽八糖
经验公式（希尔记法）:
C48H80O40
CAS号:
17465-86-0
分子量:
1297.12
Beilstein:
78740
EC 号:
241-482-4
MDL编号:
MFCD00009595
PubChem化学物质编号:
329768038
NACRES:
NA.22

等级

produced by Wacker Chemie AG, Burghausen, Germany

检测方案

≥90.0% cyclodextrin basis (HPLC)

形式

powder

缺失

≤11.0% loss on drying

SMILES string

[H][C@]1(O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O)O[C@@H]2[C@@H](COC(C)=O)O[C@H](OC(C)=O)[C@H](OC(C)=O)[C@H]2OC(C)=O

InChI

1S/C48H80O40/c49-1-9-33-17(57)25(65)41(73-9)82-34-10(2-50)75-43(27(67)19(34)59)84-36-12(4-52)77-45(29(69)21(36)61)86-38-14(6-54)79-47(31(71)23(38)63)88-40-16(8-56)80-48(32(72)24(40)64)87-39-15(7-55)78-46(30(70)22(39)62)85-37-13(5-53)76-44(28(68)20(37)60)83-35-11(3-51)74-42(81-33)26(66)18(35)58/h9-72H,1-8H2/t9-,10-,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31-,32-,33-,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-/m1/s1

InChI key

GDSRMADSINPKSL-HSEONFRVSA-N

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相关类别

一般描述

Gamma-cyclodextrin (γ-CD) is a cyclic α-1,4-glucan linked oligosaccharide that is widely used in the food and pharmaceutical industries. In drug delivery, γ-CD can be used as a complexing agent because it forms an inclusion complex with a drug molecule. The complex of cyclodextrin increases the aqueous solubility and dissolution rate of the drug, which is useful for the delivery of the medical agent to a biological system.

应用

γ-Cyclodextrin can be used as a precursor for the synthesis of:
  • Octakis-(2,3-di-O-methyl-6-O-carboxymethyl)-γ-cyclodextrin sodium salt (ODMCM). ODMCM is used in capillary electrophoresis as a chiral resolving agent.
  • Water-soluble cyclodextrin thioethers derivatives for the transportation of hydrophobic drugs.

法律信息

Cavasol is a registered trademark of Wacker Chemie AG

储存分类代码

13 - Non Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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索取COA

Single-isomer carboxymethyl-γ-cyclodextrin as chiral resolving agent for capillary electrophoresis
Benkovics G, et al.
Journal of Chromatography A, 1467(2), 445-453 (2016)
Synthesis of uniform cyclodextrin thioethers to transport hydrophobic drugs
Becker LF, et al.
Beilstein Journal of Organic Chemistry, 10(1), 2920-2927 (2014)
Safety assessment of γ-cyclodextrin
Munro IC, et al.
Regulatory Toxicology and Pharmacology, 39, 3-13 (2004)
Phatsawee Jansook et al.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 13(3), 336-350 (2010-11-26)
Study the complexation of dexamethasone in combinations of γ-cyclodextrin (γCD) and 2-hydroxypropyl-γ-cyclodextrin (HPγCD) with emphasis on solid characterization and development of aqueous dexamethasone eye drop suspension for drug delivery through sclera. Dexamethasone/cyclodextrin (dexamethasone/CD) solid complex systems were prepared and characterized
B-G Kim et al.
British journal of pharmacology, 164(6), 1698-1710 (2011-05-19)
Although 3α-hydroxy, 5α-reduced pregnane steroids, such as allopregnanolone (AlloP) and tetrahydrodeoxycorticosterone, are endogenous positive modulators of postsynaptic GABA(A) receptors, the functional roles of endogenous neurosteroids in synaptic transmission are still largely unknown. In this study, the effect of AlloP on
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