所有图片(1)

文件

807788

palmitic-acid-9-hydroxy-stearic-acid

Name: palmitic-acid-9-hydroxy-stearic-acid
Brand: ALDRICH

95%

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所有图片(1)

别名:

9-PAHSA

经验公式（希尔记法）:

C₃₄H₆₆O₄

分子量:

538.89

PubChem化学物质编号:

329768748

NACRES:

NA.22

质量水平

100

检测方案

95%

形式

solid

mp

33.5 °C

储存温度

2-8°C

SMILES字符串

CCCCCCCCCC(OC(CCCCCCCCCCCCCCC)=O)CCCCCCCC(O)=O

InChI

1S/C34H66O4/c1-3-5-7-9-11-12-13-14-15-16-18-23-27-31-34(37)38-32(28-24-20-17-10-8-6-4-2)29-25-21-19-22-26-30-33(35)36/h32H,3-31H2,1-2H3,(H,35,36)

InChI key

MHQWHZLXDBVXML-UHFFFAOYSA-N

一般描述

Palmitic-acid-9-hydroxy-stearic-acid (9-PAHSA) is an isomeric form of bioactive fatty acid ester of hydroxyl-fatty acid (FAHFA).

应用

9-PAHSA is composed of palmitic acid attached to stearic acid and is in the class of branched lipids referred to as fatty acid esters of hydroxy fatty acids (FAHFAs). 9-PAHSA was found at increased levels in serum and white adipose tissue of insulin-sensitive mice. Levels were found to be lower in white adipose tissue of insulin-resistant humans. Studies of oral administration of 9-PAHSA to obese, diabetic mice showed improved glucose tolerance. In characterizing the mechanism, it was found that 9-PAHSA stimulates insulin and GLP-1 secretion and also enhances glucose transport and the Glut4 transporter through activation of GPR-120. 9-PAHSA was also shown to have anti-inflammatory properties.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects.

Mark M Yore et al.

Cell, 159(2), 318-332 (2014-10-11)

Increased adipose tissue lipogenesis is associated with enhanced insulin sensitivity. Mice overexpressing the Glut4 glucose transporter in adipocytes have elevated lipogenesis and increased glucose tolerance despite being obese with elevated circulating fatty acids. Lipidomic analysis of adipose tissue revealed the

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