852678
6-巯基嘌呤 一水合物
98%
别名:
6-嘌呤硫醇, 6-硫代嘌呤
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关于此项目
经验公式（希尔记法）:
C5H4N4S · H2O
化学文摘社编号:
分子量:
170.19
UNSPSC Code:
12352005
NACRES:
NA.22
PubChem Substance ID:
EC Number:
200-037-4
Beilstein/REAXYS Number:
4012091
MDL number:
Assay:
98%
Form:
powder
InChI key
WFFQYWAAEWLHJC-UHFFFAOYSA-N
InChI
1S/C5H4N4S.H2O/c10-5-3-4(7-1-6-3)8-2-9-5;/h1-2H,(H2,6,7,8,9,10);1H2
SMILES string
O.Sc1ncnc2[nH]cnc12
assay
98%
form
powder
mp
>300 °C (lit.)
Quality Level
Gene Information
human ... PPAT(5471)
General description
6-巯基嘌呤一水合物是一种抗代谢物和抗肿瘤药物。它与4-羟基苯甲酸以及2,4-二羟基苯甲酸的共结晶或与哌嗪的盐形成可提高其水溶性。
Application
6-巯基嘌呤是一种广泛使用的抗白血病药物，可通过将硫嘌呤甲基转移酶代谢物插入DNA和RNA而抑制从头的嘌呤合成。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Muta. 2 - Repr. 2
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
The crystal and molecular structure of 6-mercaptopurine monohydrate.
Sletten E, et al.
Acta Crystallographica Section B, Structural Science, Crystal Engineering and Materials, 25(7), 1330-1338 (1969)
Improving the solubility of 6-Mercaptopurine via cocrystals and salts
Xu LL, et al.
Crystal Growth & Design, 12(12), 6004-6011 (2012)
William J Sandborn et al.
Gastroenterology, 146(1), 85-95 (2013-06-06)
Little is known about the efficacy of golimumab, a fully human monoclonal antibody to tumor necrosis factor (TNF) -α, for treatment of ulcerative colitis (UC). We evaluated subcutaneous golimumab induction therapy in TNF-α antagonist-naïve patients with moderate-to-severe UC despite conventional
Nabeel Khan et al.
Gastroenterology, 145(5), 1007-1015 (2013-07-31)
There is controversy over whether the treatment of patients with ulcerative colitis (UC) with thiopurines increases their risk of lymphoma. We evaluated the risk of lymphoma (ongoing, residual, and per year of therapy) among thiopurine-treated patients with UC. We obtained
Alex H Beesley et al.
Cancer research, 73(9), 2749-2759 (2013-02-26)
Patients relapsing with T-cell acute lymphoblastic leukemia (T-ALL) face a dismal outcome. The aim of this study was to identify new markers of drug resistance and clinical response in T-ALL. We measured gene expression and drug sensitivity in 15 pediatric
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