852678
6-巯基嘌呤 一水合物
98%
别名:
6-嘌呤硫醇, 6-硫代嘌呤
质量水平
方案
98%
表单
powder
mp
>300 °C (lit.)
SMILES字符串
O.Sc1ncnc2[nH]cnc12
InChI
1S/C5H4N4S.H2O/c10-5-3-4(7-1-6-3)8-2-9-5;/h1-2H,(H2,6,7,8,9,10);1H2
InChI key
WFFQYWAAEWLHJC-UHFFFAOYSA-N
基因信息
human ... PPAT(5471)
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一般描述
6-巯基嘌呤一水合物是一种抗代谢物和抗肿瘤药物。它与4-羟基苯甲酸以及2,4-二羟基苯甲酸的共结晶或与哌嗪的盐形成可提高其水溶性。
应用
6-巯基嘌呤是一种广泛使用的抗白血病药物，可通过将硫嘌呤甲基转移酶代谢物插入DNA和RNA而抑制从头的嘌呤合成。
警示用语：
Danger
危险声明
危险分类
Acute Tox. 3 Oral - Muta. 2 - Repr. 2
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
The crystal and molecular structure of 6-mercaptopurine monohydrate.
Sletten E, et al.
Acta Crystallographica Section B, Structural Science, Crystal Engineering and Materials, 25(7), 1330-1338 (1969)
Goran Marinković et al.
Journal of immunology (Baltimore, Md. : 1950), 192(9), 4370-4378 (2014-03-29)
Azathioprine and its metabolite 6-mercaptopurine (6-MP) are well established immunosuppressive drugs. Common understanding of their immunosuppressive properties is largely limited to immune cells. However, in this study, the mechanism underlying the protective role of 6-MP in endothelial cell activation is
Comparative structural and spectrum analyses of 6-mercaptopurine monohydrate and 6-mercaptopurine hydrochloride
Perez-Ruiz E, et al.
Canadian Journal of Analytical Sciences and Spectroscopy, 43(3), 59-67 (1998)
Unit-cell dimensions and space group of 6-mercaptopurine monohydrate.
Hoogsteen K.
Nature, 178(4529), 379-379 (1956)
Helmut Gadner et al.
Blood, 121(25), 5006-5014 (2013-04-17)
Langerhans cell histiocytosis (LCH)-III tested risk-adjusted, intensified, longer treatment of multisystem LCH (MS-LCH), for which optimal therapy has been elusive. Stratified by risk organ involvement (high [RO+] or low [RO-] risk groups), > 400 patients were randomized. RO+ patients received
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