861545
N10-(三氟乙酰基)蝶酸
95%
别名:
4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl](2,2,2-trifluoroacetyl)amino]benzoic acid, N10-Trifluoroacetylpteroic acid
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关于此项目
经验公式（希尔记法）:
C16H11F3N6O4
化学文摘社编号:
分子量:
408.29
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
Assay:
95%
Form:
solid
Quality Level
assay
95%
form
solid
mp
270 °C (dec.) (lit.)
functional group
amide, carboxylic acid, fluoro
SMILES string
Nc1nc(O)c2nc(CN(c3ccc(cc3)C(O)=O)C(=O)C(F)(F)F)cnc2n1
InChI
1S/C16H11F3N6O4/c17-16(18,19)14(29)25(9-3-1-7(2-4-9)13(27)28)6-8-5-21-11-10(22-8)12(26)24-15(20)23-11/h1-5H,6H2,(H,27,28)(H3,20,21,23,24,26)
InChI key
IJGIHDXKYQLIMA-UHFFFAOYSA-N
Application
N10-(Trifluoroacetyl)pteroic acid is a structural component of folic acid. It can be used as a precursor to synthesize folic acid derivatives, γ-azido modified folic acid, and pteroyl-γ-glutamate-cysteine.
Other Notes
残余 DMF
signalword
Danger
Hazard Classifications
Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
Pteroyl-γ-glutamate-cysteine synthesis and its application in folate receptor-mediated cancer cell targeting using folate-tethered liposomes.
Zhang Y, et al.
Analytical Biochemistry, 332(1), 168-177 (2004)
The facile synthesis of multifunctional PAMAM dendrimer conjugates through copper-free click chemistry.
Huang B, et al.
Bioorganic & Medicinal Chemistry Letters, 22(9), 3152-3156 (2012)
Self?Assembly of Folic Acid Derivatives: Induction of Supramolecular Chirality by Hierarchical Chiral Structures.
Kamikawa Y, et al.
Chemistry?A European Journal , 10(23), 5942-5951 (2004)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 861545-25MG | 04061833282205 |