861650
(+)-生物素 4-硝基苯酯
98%
别名:
4-硝基苯基 (+)-生物素酯, d-生物素对硝基苯酯, BNP
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关于此项目
经验公式（希尔记法）:
C16H19N3O5S
化学文摘社编号:
分子量:
365.40
UNSPSC Code:
12352108
NACRES:
NA.22
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
5795805
Assay:
98%
Form:
powder
产品名称
(+)-生物素 4-硝基苯酯, 98%
InChI key
YUDNXDTXQPYKCA-YDHLFZDLSA-N
SMILES string
[O-][N+](=O)c1ccc(OC(=O)CCCC[C@@H]2SCC3NC(=O)NC23)cc1
InChI
1S/C16H19N3O5S/c20-14(24-11-7-5-10(6-8-11)19(22)23)4-2-1-3-13-15-12(9-25-13)17-16(21)18-15/h5-8,12-13,15H,1-4,9H2,(H2,17,18,21)/t12-,13-,15-/m0/s1
assay
98%
form
powder
optical activity
[α]25/D +51°, c = 2 in DMF: AcOH (99:1)
mp
163-165 °C (lit.)
solubility
methanol: 25 mg/mL, clear, colorless to greenish-yellow
functional group
ester
nitro
thioether
Quality Level
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Application
(+)-生物素-4-硝基苯酯可用于在细胞蛋白摄取研究中制备生物素标记ARC（腺苷-寡聚精氨酸偶联物）衍生物。也可用于制备生物素化喹唑啉衍生物抑制VEGFR-2酪氨酸（血管内皮生长因子受体-2）激酶活性。(+)-生物素-4-硝基苯酯在Na[17O]H存在下，水解形成[17O2]生物素用于17O核磁共振波谱法分析蛋白-配体大复合物。
使用Synple自动合成平台(SYNPLE-SC002)实现自动化生物素标记
使用Synple自动合成平台(SYNPLE-SC002)实现自动化生物素标记
Packaging
无底玻璃瓶。内含物装在插入的融合锥内。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Solomon K Musani et al.
Circulation. Cardiovascular genetics, 8(1), 122-130 (2015-01-07)
Numerous experimental studies suggest that B-type natriuretic peptide (BNP) is cardioprotective; however, in clinical studies, higher plasma BNP concentrations have been associated with incident cardiovascular disease and higher left ventricular mass. Genetic association studies may allow us to determine the
Abhinav Sharma et al.
European journal of heart failure, 19(10), 1310-1320 (2017-06-24)
It is unclear whether distinct pathophysiological processes are present among patients with acute heart failure (AHF), with and without diabetes. Network analysis of biomarkers may identify correlative associations that reflect different pathophysiological pathways. We analysed a panel of 48 circulating
Jing Zong et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 48(1), 75-86 (2018-07-13)
Nuclear localization leucine-rich-repeat protein 1 (NLRP1) is a cytoplasmic protein, involved in autoimmune diseases, mammalian reproduction, neuronal cell death, and stroke. However, the role of NLRP1 in cardiac hypertrophy remains unclear. We used in vivo and in vitro models to
Synthesis of a novel biotin-tagged photoaffinity probe for VEGF receptor tyrosine kinases.
Han SY, et al.
Bioorganic & Medicinal Chemistry Letters, 16(1), 129-133 (2006)
Solid-State 17O NMR Spectroscopy of Large Protein-Ligand Complexes.
Zhu J, et al.
Angewandte Chemie (International Edition in English), 49(45), 8399-8402 (2010)
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