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经验公式(希尔记法):
C16H19N3O5S
化学文摘社编号:
分子量:
365.40
UNSPSC Code:
12352108
NACRES:
NA.22
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
5795805
Assay:
98%
Form:
powder
产品名称
(+)-生物素 4-硝基苯酯, 98%
InChI key
YUDNXDTXQPYKCA-YDHLFZDLSA-N
SMILES string
[O-][N+](=O)c1ccc(OC(=O)CCCC[C@@H]2SCC3NC(=O)NC23)cc1
InChI
1S/C16H19N3O5S/c20-14(24-11-7-5-10(6-8-11)19(22)23)4-2-1-3-13-15-12(9-25-13)17-16(21)18-15/h5-8,12-13,15H,1-4,9H2,(H2,17,18,21)/t12-,13-,15-/m0/s1
assay
98%
form
powder
optical activity
[α]25/D +51°, c = 2 in DMF: AcOH (99:1)
mp
163-165 °C (lit.)
solubility
methanol: 25 mg/mL, clear, colorless to greenish-yellow
functional group
ester
nitro
thioether
Quality Level
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Application
(+)-生物素-4-硝基苯酯可用于在细胞蛋白摄取研究中制备生物素标记ARC(腺苷-寡聚精氨酸偶联物)衍生物。也可用于制备生物素化喹唑啉衍生物抑制VEGFR-2酪氨酸(血管内皮生长因子受体-2)激酶活性。(+)-生物素-4-硝基苯酯在Na[17O]H存在下,水解形成[17O2]生物素用于17O核磁共振波谱法分析蛋白-配体大复合物。
使用Synple自动合成平台(SYNPLE-SC002)实现自动化生物素标记
使用Synple自动合成平台(SYNPLE-SC002)实现自动化生物素标记
Packaging
无底玻璃瓶。内含物装在插入的融合锥内。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Solid-State 17O NMR Spectroscopy of Large Protein-Ligand Complexes.
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Angewandte Chemie (International Edition in English), 49(45), 8399-8402 (2010)
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Björn Redfors et al.
Circulation (2018-04-19)
Background -Elevated B-type natriuretic peptide (BNP) is reflective of impaired cardiac function and is associated with worse prognosis among
Isabel Amador-Martínez et al.
American journal of physiology. Renal physiology, 317(2), F275-F285 (2019-05-23)
Major cardiovascular events are a common complication in patients with chronic kidney disease (CKD). Endothelial dysfunction can contribute to the cardiovascular injury observed in CKD. Here, we used a rat model of acute kidney injury to CKD transition to investigate
Identification of the ability of highly charged nanomolar inhibitors of protein kinases to cross plasma membranes and carry a protein into cells.
Uri A, et al.
Bioorganic & Medicinal Chemistry Letters, 12(16), 2117-2120 (2002)
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