861650
(+)-生物素 4-硝基苯酯
98%
别名:
4-硝基苯基 (+)-生物素酯, d-生物素对硝基苯酯, BNP
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关于此项目
经验公式（希尔记法）:
C16H19N3O5S
化学文摘社编号:
分子量:
365.40
Beilstein:
5795805
MDL编号:
UNSPSC代码:
12352108
PubChem化学物质编号:
NACRES:
NA.22
质量水平
方案
98%
表单
powder
旋光性
[α]25/D +51°, c = 2 in DMF: AcOH (99:1)
mp
163-165 °C (lit.)
溶解性
methanol: 25 mg/mL, clear, colorless to greenish-yellow
官能团
ester
nitro
thioether
SMILES字符串
[O-][N+](=O)c1ccc(OC(=O)CCCC[C@@H]2SCC3NC(=O)NC23)cc1
InChI
1S/C16H19N3O5S/c20-14(24-11-7-5-10(6-8-11)19(22)23)4-2-1-3-13-15-12(9-25-13)17-16(21)18-15/h5-8,12-13,15H,1-4,9H2,(H2,17,18,21)/t12-,13-,15-/m0/s1
InChI key
YUDNXDTXQPYKCA-YDHLFZDLSA-N
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应用
(+)-生物素-4-硝基苯酯可用于在细胞蛋白摄取研究中制备生物素标记ARC（腺苷-寡聚精氨酸偶联物）衍生物。也可用于制备生物素化喹唑啉衍生物抑制VEGFR-2酪氨酸（血管内皮生长因子受体-2）激酶活性。(+)-生物素-4-硝基苯酯在Na[17O]H存在下，水解形成[17O2]生物素用于17O核磁共振波谱法分析蛋白-配体大复合物。
使用Synple自动合成平台(SYNPLE-SC002)实现自动化生物素标记
使用Synple自动合成平台(SYNPLE-SC002)实现自动化生物素标记
包装
无底玻璃瓶。内含物装在插入的融合锥内。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Abhinav Sharma et al.
European journal of heart failure, 19(10), 1310-1320 (2017-06-24)
It is unclear whether distinct pathophysiological processes are present among patients with acute heart failure (AHF), with and without diabetes. Network analysis of biomarkers may identify correlative associations that reflect different pathophysiological pathways. We analysed a panel of 48 circulating
Jing Zong et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 48(1), 75-86 (2018-07-13)
Nuclear localization leucine-rich-repeat protein 1 (NLRP1) is a cytoplasmic protein, involved in autoimmune diseases, mammalian reproduction, neuronal cell death, and stroke. However, the role of NLRP1 in cardiac hypertrophy remains unclear. We used in vivo and in vitro models to
Solomon K Musani et al.
Circulation. Cardiovascular genetics, 8(1), 122-130 (2015-01-07)
Numerous experimental studies suggest that B-type natriuretic peptide (BNP) is cardioprotective; however, in clinical studies, higher plasma BNP concentrations have been associated with incident cardiovascular disease and higher left ventricular mass. Genetic association studies may allow us to determine the
Synthesis of a novel biotin-tagged photoaffinity probe for VEGF receptor tyrosine kinases.
Han SY, et al.
Bioorganic & Medicinal Chemistry Letters, 16(1), 129-133 (2006)
Isabel Amador-Martínez et al.
American journal of physiology. Renal physiology, 317(2), F275-F285 (2019-05-23)
Major cardiovascular events are a common complication in patients with chronic kidney disease (CKD). Endothelial dysfunction can contribute to the cardiovascular injury observed in CKD. Here, we used a rat model of acute kidney injury to CKD transition to investigate
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