86734
1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸
≥97.0% (CHN)
别名:
DOTA
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关于此项目
经验公式（希尔记法）:
C16H28N4O8 · xH2O
化学文摘社编号:
分子量:
404.42 (anhydrous basis)
Beilstein:
1186987
MDL编号:
UNSPSC代码:
12352005
PubChem化学物质编号:
NACRES:
NA.22
质量水平
方案
≥97.0% (CHN)
表单
powder
官能团
carboxylic acid
SMILES字符串
OC(=O)CN1CCN(CCN(CCN(CC1)CC(O)=O)CC(O)=O)CC(O)=O
InChI
1S/C16H28N4O8/c21-13(22)9-17-1-2-18(10-14(23)24)5-6-20(12-16(27)28)8-7-19(4-3-17)11-15(25)26/h1-12H2,(H,21,22)(H,23,24)(H,25,26)(H,27,28)
InChI key
WDLRUFUQRNWCPK-UHFFFAOYSA-N
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应用
1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸(DOTA)是一种大环络合剂。
- 它已用于通过螯合64Cu放射性同位素进行碳纳米管生物偶联物的放射性标记。
- DOTA可被N-羟基琥珀酰亚胺基活化，进而与单克隆抗体偶联，用于临床放射免疫治疗。
- 它可与钆形成配合物用作MRI造影剂。
- DOTA肽偶联物的金属配合物可用作治疗用放射性药物。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
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