900584
5-乙炔基-2′-脱氧尿苷
95%
别名:
EdU
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关于此项目
经验公式（希尔记法）:
C11H12N2O5
化学文摘社编号:
分子量:
252.22
MDL number:
UNSPSC Code:
12352208
NACRES:
NA.22
产品名称
5-乙炔基-2′-脱氧尿苷, 95%
SMILES string
OC[C@@H]1[C@@H](O)C[C@H](N2C(NC(C(C#C)=C2)=O)=O)O1
InChI
1S/C11H12N2O5/c1-2-6-4-13(11(17)12-10(6)16)9-3-7(15)8(5-14)18-9/h1,4,7-9,14-15H,3,5H2,(H,12,16,17)/t7-,8+,9+/m0/s1
InChI key
CDEURGJCGCHYFH-DJLDLDEBSA-N
assay
95%
form
powder
mp
206 °C
storage temp.
−20°C
Quality Level
Application
5-乙炔基-2′-脱氧尿苷（EdU）用于：
有关Baseclick试剂盒的列表，参见：Baseclick试剂盒
- 在复制过程中标记新合成的DNA
- 细胞增殖试验研究
- 细胞周期分析
有关Baseclick试剂盒的列表，参见：Baseclick试剂盒
General description
5-乙炔基-2′-脱氧尿苷（EdU）是一种胸苷类似物，可掺入到细胞DNA中，以进行细胞增殖研究。所掺入的核苷类似物可以通过与荧光叠氮化物的铜催化点击反应来检测。
signalword
Danger
hcodes
Hazard Classifications
Muta. 1B - Repr. 2
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Site-directed spin-labeling of nucleic acids by click chemistry: detection of abasic sites in duplex DNA by EPR spectroscopy.
Jakobsen A, et al.
Journal of the American Chemical Society, 132(30), 10424-10428 (2010)
Detection of S-phase cell cycle progression using 5-ethynyl-2?-deoxyuridine incorporation with click chemistry, an alternative to using 5-bromo-2?-deoxyuridine antibodies
SB Buck
Biotechniques, 44, 927-929 (2008)
Quantification of cell cycle kinetics by EdU (5-ethynyl-2?-deoxyuridine)-coupled-fluorescence-intensity analysis
PD Pereira
Oncotarget, 8, 40514-40514 (2017)
Timothy J Mead et al.
Methods in molecular biology (Clifton, N.J.), 1130, 233-243 (2014-02-01)
Assessing cell proliferation in situ is an important phenotyping component of skeletal tissues from development to adult stages and disease. Various methods exist including immunostaining for proteins and protein modifications associated with specific steps of the cell cycle, but the
Click chemistry as a reliable method for the high-density postsynthetic functionalization of alkyne-modified DNA.
Gierlich J, et al.
Organic Letters, 8(17), 3639-3642 (2006)
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