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Merck
CN

900601

3-Formyl-5-((trimethylsilyl)ethynyl)benzenesulfonyl fluoride

≥95%

别名:

Formyl sulfonyl fluoride alkyne, Probe building block

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关于此项目

经验公式（希尔记法）:
C12H13FO3SSi
化学文摘社编号:
2088829-13-2
分子量:
284.38
UNSPSC Code:
12352200
NACRES:
NA.22

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产品名称

3-Formyl-5-((trimethylsilyl)ethynyl)benzenesulfonyl fluoride, ≥95%

SMILES string

O=C([H])C1=CC(S(=O)(F)=O)=CC(C#C[Si](C)(C)C)=C1

assay

≥95%

form

solid

reaction suitability

reaction type: click chemistry

storage temp.

−20°C

Application

3-Formyl-5-((trimethylsilyl)ethynyl)benzenesulfonyl fluoride is used for chemical probe synthesis, this trifunctional building block contains an aryl sulfonyl fluoride group, alkyne tag, and aldehyde synthetic handle. When appended to a ligand or pharmacophore through its formyl group, this building block allows for SuFEx-enabled, context-specific covalent modification of a biological target with potential for downstream applications via the alkyne tag. Use alone or in parallel with other multi-functional building blocks to discover the optimal probe for your chemical biology experiments.

Other Notes


Technology Spotlight: Trifuctional Probe Building Blocks

Chemoselective Preparation of Clickable Aryl Sulfonyl Fluoride Monomers: A Toolbox of Highly Functionalized Intermediates for Chemical Biology Probe Synthesis

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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Trifunctional Probe Building Blocks

In partnership with Pfizer chemists, we have compiled a collection of trifunctional building blocks to enable development of probes.

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