2,5-二溴己二酰胺

Name: 2,5-二溴己二酰胺
Brand: ALDRICH

≥95%

别名:

2,5-Dibromoadipamide, DBHDA

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关于此项目

经验公式（希尔记法）:

C₆H₁₀Br₂N₂O₂

化学文摘社编号:

99584-96-0

分子量:

301.96

UNSPSC Code:

12352200

NACRES:

NA.22

MDL number:

MFCD27976335

Assay:

≥95%

Form:

solid

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属性

Quality Level

100

assay

≥95%

form

solid

storage temp.

2-8°C

SMILES string

BrC(CCC(Br)C(=O)N)C(=O)N

InChI

1S/C6H10Br2N2O2/c7-3(5(9)11)1-2-4(8)6(10)12/h3-4H,1-2H2,(H2,9,11)(H2,10,12)

InChI key

PLSXNAQEJOGNKQ-UHFFFAOYSA-N

说明

Application

This compound has been shown to be a useful reagent for the conversion of cysteine to dehydroalanine (DHA) in peptides or proteins. This enables chemical mutagenesis in which DHA can be efficiently reacted with iodide building blocks to add various natural and unnatural side chains on proteins. It was also shown that other modifications could be added through DHA such as phosphorylation, methylation, and glycosylation. In other research it was shown that DHA can be used to make ubiquitin conjugates that have a bond that mimics the native isopeptide bond.