900755
SLAP TA
95%
别名:
3-(((Trimethylsilyl)methyl)thio)propan-1-amine
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关于此项目
经验公式（希尔记法）:
C7H19NSSi
化学文摘社编号:
分子量:
177.38
MDL number:
UNSPSC Code:
12352103
NACRES:
NA.22
Quality Segment
assay
95%
form
liquid
density
0.90452
functional group
amine, thioether
storage temp.
2-8°C
SMILES string
[Si](CSCCCN)(C)(C)C
InChI
1S/C7H19NSSi/c1-10(2,3)7-9-6-4-5-8/h4-8H2,1-3H3
InChI key
CNESDLLESCAVSR-UHFFFAOYSA-N
Application
When used with aliphatic or aromatic aldehydes, this silicon amine protocol SLAP reagent enables the photomediated synthesis of thiomorpholines and thiazepanes. For photocatalytic cross-coupling with this SLAP Reagent, Ir[(ppy)2dtbbpy]PF6 (747769) is used with a recommended starting combination of Lewis acids Bi(OTf)3 (633305) and Cu(OTf)2 (283673) prior to subsequent substrate-specific optimization. This product was introduced in collaboration with the Bode Research Group and provides a tin-free alternative to SnAP (tin amine protocol) reagents and is well-suited for scale-up reactions.
Other Notes
- Technology Spotlight: SLAP Reagents for Piperazine Synthesis
- Silicon Amine Reagents for the Photocatalytic Synthesis of Piperazines from Aldehydes and Ketones
- Lewis Acid Induced Toggle from Ir(II) to Ir(IV) Pathways in Photocatalytic Reactions: Synthesis of Thiomorpholines and Thiazepanes from Aldehydes and SLAP Reagents.
- Continuous Flow Synthesis of Morpholines and Oxazepanes with Silicon Amine Protocol (SLAP) Reagents and Lewis Acid Facilitated Photoredox Catalysis
signalword
Warning
hcodes
pcodes
Hazard Classifications
Flam. Liq. 3
存储类别
3 - Flammable liquids
wgk
WGK 3
flash_point_f
75.0 °F
flash_point_c
23.89 °C