901422
聚 N -异丙基丙烯酰胺
average Mn 85,000
别名:
NIPAM 聚合物, PNIPAM, 聚NIPAM, 聚丙烯酰胺
表单
crystals
分子量
Mn 60,000-110,000 Da by MALLS (GPC)
average Mn 85,000
颜色
white to off-white
mp
96 °C
储存温度
2-8°C
SMILES字符串
CC(C)NC(=O)C=C
InChI
1S/C6H11NO/c1-3-5-7-6(8)4-2/h4H,2-3,5H2,1H3,(H,7,8)
InChI key
WDFKEEALECCKTJ-UHFFFAOYSA-N
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一般描述
聚 （N-异丙基丙烯酰胺）（PNIPAM） 是一种用于生物医学研究应用的温度响应型聚合物。当加热到 32 °C 以上时，PNIPAM 经历可逆的低临界溶解温度（LCST)）相变，由可溶性材料转变为不溶性材料。PNIPAM 也经常进行交联以产生具有可逆、热收缩和膨胀的水凝胶。聚 （N-异丙基丙烯酰胺）也易于官能化，并已在热响应性两亲性嵌段共聚物的合成中用作亲水嵌段。由于 PNIPAM 的 LCST 温度与人体温度相似，PNIPAM 材料常被用于组织工程和受控药物递送研究应用。
应用
PNIPAM 可用于形成智能水凝胶，智能水凝胶可用于传感器、燃料电池、超级电容器和锂离子电池。它还可用于制造分子纳米温度计。 PNIPAM 表面涂布金纳米粒子 （AuNP） 以形成微凝胶，微凝胶有助于形成表面增强拉曼散射 (SERS) 的高度可重复信号。
热敏聚合物可用于形成水凝胶。当温度升至ca. 32 °C时，聚合物水溶液发生相变，即从可溶状态转变为不溶状态。
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Au@ pNIPAM colloids as molecular traps for surface-enhanced, spectroscopic, ultra-sensitive analysis
Alvarez-Puebla RA, et al.
Angewandte Chemie (International ed. in English), 48(1), 138-143 (2009)
Nanorod-coated PNIPAM microgels: thermoresponsive optical properties
Karg M, et al.
Small, 3(7), 1222-1229 (2007)
Muhammad Abdul Haq et al.
Materials science & engineering. C, Materials for biological applications, 70(Pt 1), 842-855 (2016-10-25)
Materials which adjust their properties in response to environmental factors such as temperature, pH and ionic strength are rapidly evolving and known as smart materials. Hydrogels formed by smart polymers have various applications. Among the smart polymers, thermoresponsive polymer poly(N-isopropylacrylamide)(PNIPAM)
Synthesis of hyperbranched polyglycidol-b-poly(N-isopropylacrylamide) using nitroxide-mediated polymerization for thermo-sensitive drug delivery system.
Min Seon Heo et al.
Journal of controlled release : official journal of the Controlled Release Society, 213, e80-e80 (2016-03-24)
Poly (N-isopropylacrylamide)(PNIPAM) is never hydrophobic
Pelton R, et al.
Journal of Colloid and Interface Science, 348(2), 673-674 (2010)
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