902535
Amino-PEG4-t-butyl ester
别名:
tert-Butyl 1-amino-3,6,9,12-tetraoxapentadecan-15-oate, H2N-PEG4-CH2CH2COOtBu, H2N-dPEG(4)-CO-OtBu
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关于此项目
经验公式（希尔记法）:
C15H31NO6
化学文摘社编号:
分子量:
321.41
UNSPSC Code:
51171641
NACRES:
NA.22
MDL number:
InChI
1S/C15H31NO6/c1-15(2,3)22-14(17)4-6-18-8-10-20-12-13-21-11-9-19-7-5-16/h4-13,16H2,1-3H3
SMILES string
NCCOCCOCCOCCOCCC(OC(C)(C)C)=O
InChI key
PKESARRNSGIDRD-UHFFFAOYSA-N
form
liquid
reaction suitability
reagent type: cross-linking reagent
refractive index
n/D 1.4508
density
1.04479 g/mL
functional group
amine
ester
storage temp.
−20°C
Application
This heterobifunctional, PEGylated crosslinker features an amino group at one end and t-butyl-protected carboxyl group at the other, which can be deprotected with acidic conditions. The hydrophilic PEG linker facilitates solubility in biological applications. Amino-PEG4-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation.
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Other Notes
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Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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