CN
所有图片(1)
别名:
2,2-Dimethyl-4-oxo-3,8,11,14,17-pentaoxa-5-azanonadecan-19-oic acid, Boc-NH-PEG4-CH2COOH
经验公式（希尔记法）:
C15H29NO8
CAS号:
分子量:
351.39
形式
liquid
反应适用性
reaction type: Pegylations
reagent type: cross-linking reagent
折射率
n/D 1.4641
密度
1.1395 g/mL
官能团
Boc
amine
carboxylic acid
储存温度
−20°C
SMILES字符串
OC(COCCOCCOCCOCCNC(OC(C)(C)C)=O)=O
应用
This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and Boc-protected amino group at the other, which can be deprotected with mildly acidic conditions. The hydrophilic PEG linker facilitates solubility in biological applications. BocNH-PEG4-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation
Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation
Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation
其他说明
法律信息
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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A biocompatible condensation reaction for the labeling of terminal cysteine residues on proteins.
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Angewandte Chemie (International ed. in English), 48(51), 9658-9662 (2009-11-20)
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ACS chemical biology, 8(4), 691-699 (2013-01-12)
Bioorthogonal ligation methods that allow the selective conjugation of fluorophores or biotin to proteins and small molecule probes that contain inert chemical handles are an important component of many chemical proteomic strategies. Here, we present a new catch-and-release enrichment strategy
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Rosnizeck I C, et al.
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BisPNA targeting to DNA: Effect of neutral loop on DNA duplex strand invasion by aepPNA-N7GlaepPNA-C substituted peptide nucleic acids
Shirude P S, et sl.
European Journal of Organic Chemistry, 2005, 5207-5215 (2005)
Pratistha Ranjitkar et al.
Chemistry & biology, 17(2), 195-206 (2010-03-02)
A number of small-molecule inhibitors have been developed that target the catalytic domains of protein kinases that are not in an active conformation. An inactive form that has been observed in several kinases is the DFG-out conformation. This conformation is
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