表单
liquid
反应适用性
reaction type: Pegylations
reagent type: cross-linking reagent
折射率
n/D 1.4641
密度
1.1395 g/mL
官能团
Boc
amine
carboxylic acid
储存温度
−20°C
SMILES字符串
OC(COCCOCCOCCOCCNC(OC(C)(C)C)=O)=O
InChI
1S/C15H29NO8/c1-15(2,3)24-14(19)16-4-5-20-6-7-21-8-9-22-10-11-23-12-13(17)18/h4-12H2,1-3H3,(H,16,19)(H,17,18)
InChI key
SHMYENBXRNPSOG-UHFFFAOYSA-N
应用
This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and Boc-protected amino group at the other, which can be deprotected with mildly acidic conditions. The hydrophilic PEG linker facilitates solubility in biological applications. BocNH-PEG4-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation
Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation
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其他说明
法律信息
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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