904848
2-Chloro-1,3-bis(2,6-diisopropylphenyl)imidazolium chloride
≥95%
别名:
1,3-Bis(2,6-di-i-propylphenyl)-2-chloroimidazolium chloride, Chloroimidazolium chloride
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选择尺寸
关于此项目
经验公式（希尔记法）:
C27H36Cl2N2
化学文摘社编号:
分子量:
459.49
UNSPSC Code:
12352101
NACRES:
NA.22
MDL number:
SMILES string
[Cl+]=C1N(C=CN1c3c(cccc3C(C)C)C(C)C)c2c(cccc2C(C)C)C(C)C.[Cl-]
InChI
1S/C27H36ClN2.ClH/c1-17(2)21-11-9-12-22(18(3)4)25(21)29-15-16-30(27(29)28)26-23(19(5)6)13-10-14-24(26)20(7)8;/h9-20H,1-8H3;1H/q+1;/p-1
InChI key
JDMACANGISWEGX-UHFFFAOYSA-M
assay
≥95%
form
powder
functional group
chloro
Application
This chloroimidazolium chloride is used in the deoxyfluorination of phenols. Recently, the Ritter lab used it in conjunction with 902314 and 906794 to incorporate the [18F]fluoride radiolabel site specifically into polypeptides for use with positron emission tomography (PET) imaging in the study of various biological applications.
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Daniel Mendoza-Espinosa et al.
Journal of the American Chemical Society, 132(21), 7264-7265 (2010-05-07)
Using the nucleophilicity of NHCs and aNHCs, as well as the leaving group ability of the former, the carbon-carbon double bond of imidazol-2-ylidenes can be readily mono- and difunctionalized. These results provide also a new light on the formation of
Robert J Gilliard et al.
Chemical communications (Cambridge, England), 53(91), 12325-12328 (2017-11-03)
The reaction of the chloroimidazolium chloride salt, [NHC-Cl][Cl], NHC = C{N(2,6-iPr2C6H3)CH}2 (1) with two equivalents of sodium phosphaethynolate, Na[OCP]·(dioxane)2.5, results in the formation of NHC-{cyclo-(CO)-P2-C(O)} (2) and NHC-P2-C(O)-NHC (3). Notably, in the presence of free NHC ligand, compound 2 converts
M Hassan Beyzavi et al.
ACS central science, 3(9), 944-948 (2017-10-06)
The deficiency of robust and practical methods for 18F-radiofluorination is a bottleneck for positron emission tomography (PET) tracer development. Here, we report the first transition-metal-assisted 18F-deoxyfluorination of phenols. The transformation benefits from readily available phenols as starting materials, tolerance of
Martin G Strebl et al.
ACS central science, 3(9), 1006-1014 (2017-10-06)
Histone deacetylase 6 (HDAC6) function and dysregulation have been implicated in the etiology of certain cancers and more recently in central nervous system (CNS) disorders including Rett syndrome, Alzheimer's and Parkinson's diseases, and major depressive disorder. HDAC6-selective inhibitors have therapeutic
Jisu Back et al.
Journal of the American Chemical Society, 139(43), 15300-15303 (2017-10-19)
Notwithstanding the notable progress in the synthesis of N-heterocyclic carbene-stabilized radicals, aminyl radicals, supported by NHCs or otherwise, have been scarcely studied due to synthetic challenges. Triazenyl radical is a particular form of aminyl radical that contains three adjacent nitrogen
相关内容
The Ritter lab currently focuses on fluorination chemistry for late-stage functionalization of complex natural and unnatural products. PhenoFluor™ has been developed as a general reagent for the selective, predictable, direct deoxyfluorination of complex alcohols and phenols.
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