form
powder, crystals or chunks
storage temp.
−20°C
Application
This bis(neopentyltrimethylammonium) oxalate is used in the elution step of the Ritter lab′s new method for deoxyfluorination of phenols. First, an Fmoc-protected ruthenium tyrosine amino acid derivative ([CpRu(Fmoc-tyrosin)]CF3CO2, cat# 902314) is incorporated to a peptide. Later, bis(neopentyltrimethylammonium) oxalate and chloroimidazolium chloride (cat# 904848) facilitate the elution of [18F]fluoride. The final [18F]fluoride radiolabeled polypeptide is useful in positron emission tomography (PET) imaging for the study of various biological applications.
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Disclaimer
Bis(neopentyltrimethylammonium) oxalate is hygroscopic and should be stored in a closed vial or in a desiccator.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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Jens Rickmeier et al.
Angewandte Chemie (International ed. in English), 57(43), 14207-14211 (2018-09-07)
Radiolabeled receptor-binding peptides are an important class of positron emission tomography tracers owing to achievable high binding affinities and their rapid blood clearance. Herein, a method to introduce a 4-[18 F]fluoro-phenylalanine residue into peptide sequences is reported, by chemoselective radio-deoxyfluorination
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