907375
H-L-Photo-methionine HCl
≥95%
别名:
(S)-2-Amino-4-(3-methyl-3H-diazirin-3-yl)butanoic acid hydrochloride, (S)-2-Amino-4-(3H-diazirin-3-yl)pentanoic acid hydrochloride, Diazirine amino acid, Photo-Met, Photo-crosslinking amino acid, Photoprobe building block
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关于此项目
assay
≥95%
form
powder
reaction suitability
reaction type: solution phase peptide synthesis
availability
available only in USA
application(s)
peptide synthesis
storage temp.
2-8°C
Application
H-L-Photo-Methionine HCl is a diazirine-containing methionine amino acid and multifunctional photo-crosslinker. Its incorporation into peptides or small-molecule probes and tools allows for photoaffinity labeling of cellular targets and protein-protein interactions upon UV light (~360 nm) irradiation to form a covalent bond. This and other multifunctional probe building blocks will continue to accelerate drug discovery research for probing cellular mechanisms, target ID/validation, and understanding traditionally undruggable targets. An Fmoc-protected version is also available as 907367.
Product can be used with our line of photoreactors: Including Penn PhD (Z744035) & SynLED 2.0 (Z744080)
Product can be used with our line of photoreactors: Including Penn PhD (Z744035) & SynLED 2.0 (Z744080)
Other Notes
Carboxyl-Photo-Reactive MS-Cleavable Cross-Linkers: Unveiling a Hidden Aspect of Diazirine-Based Reagents
A vimentin binding small molecule leads to mitotic disruption in mesenchymal cancer
Cell-Based Proteome Profiling of Potential Dasatinib Targets by Use of Affinity-Based Probes
Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe
Photo-leucine and photo-methionine allow identification of protein-protein interactions in living cells
Fishing for Drug Targets: A Focus on Diazirine Photoaffinity Probe Synthesis
Photo-affinity labeling (PAL) in chemical proteomics: a handy tool to investigate protein-protein interactions (PPIs)
A vimentin binding small molecule leads to mitotic disruption in mesenchymal cancer
Cell-Based Proteome Profiling of Potential Dasatinib Targets by Use of Affinity-Based Probes
Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe
Photo-leucine and photo-methionine allow identification of protein-protein interactions in living cells
Fishing for Drug Targets: A Focus on Diazirine Photoaffinity Probe Synthesis
Photo-affinity labeling (PAL) in chemical proteomics: a handy tool to investigate protein-protein interactions (PPIs)
signalword
Danger
hcodes
Hazard Classifications
Self-react. C
存储类别
5.2 - Organic peroxides and self-reacting hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Yeolin Lee et al.
Analytical chemistry, 88(19), 9503-9509 (2016-09-01)
Fc-specific antibody binding proteins (FcBPs) with the minimal domain of protein G are widely used for immobilization of well-oriented antibodies onto solid surfaces, but the noncovalently bound antibodies to FcBPs are unstable in sera containing large amounts of antibodies. Here
Claudio Iacobucci et al.
Analytical chemistry, 90(4), 2805-2809 (2018-01-30)
A major challenge in cross-linking/mass spectrometry (MS) is targeting carboxyl functions in proteins under physiological conditions that do not disturb the protein's conformation. Cross-linking of glutamic acid and aspartic acid residues in proteins will greatly expand the scope of structural
Xiaozhou Luo et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(13), 3615-3620 (2016-03-16)
Thiopeptides are a subclass of ribosomally synthesized and posttranslationally modified peptides (RiPPs) with complex molecular architectures and an array of biological activities, including potent antimicrobial activity. Here we report the generation of thiopeptides containing noncanonical amino acids (ncAAs) by introducing
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 907375-100MG | 04022536044675 |