909432
Fluorinated VHL Spy Molecule 2
≥98%
别名:
(2S,4R)-N-(4-bromobenzyl)-4-hydroxy-1-(2,2,2-trifluoroacetyl)pyrrolidine-2-carboxamide, VHL reporter ligand
SMILES string
O=C([C@@H]1C[C@@H](O)CN1C(C(F)(F)F)=O)NCC2=CC=C(Br)C=C2
ligand
VH032 derivative
assay
≥98%
form
powder
Application
Fluorinated VHL Spy Molecule 2 can be used for the discovery of new von Hippel-Lindau (VHL) binders. Based on VH032 (cat# 901490), this reporter was designed in the lab of Alessio Ciulli to bind the hydroxyproline (Hyp) recognition site of VHL. When used in competition ligand-observed 19F NMR screening experiments, its displacement indicates binding by another molecule. Additional Fluorinated VHL Spy Molecules are available as listings 909459, 909440, and 909416.
The E3 ligase VHL is of growing interest for targeted protein degradation and these spy molecules will facilitate the identification of novel VHL ligands and VHL-based degraders.
The E3 ligase VHL is of growing interest for targeted protein degradation and these spy molecules will facilitate the identification of novel VHL ligands and VHL-based degraders.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
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