产品名称
Poly(2-(diethylamino)ethyl methacrylate), average Mn 10,000
form
powder or solid
mol wt
average Mn 10,000 (by NMR)
average Mn 10,000
color
white to faint yellow
PDI
≤1.3 (by GPC)
storage temp.
2-8°C
Application
Poly(diethylaminoethyl methacrylate) is a pH-responsive polymer. pH-Responsive polymers are a group of stimuli-responsive polymers that can respond to solution pH by undergoing structural and property changes such as surface activity, chain conformation, solubility, and configuration. The term “pH-responsive polymers” is commonly used to describe polymers having ionisable acidic or basic residues whose ionization depends on solution pH. The physical properties of the polymer, such as its chain conformation, configuration, and solubility, can be tailored by manipulating the pH or ionic strength. These unique properties of pH responsive polymer systems consequently make them very useful in various applications such as drug delivery, gene delivery, sensors, surfaces, membranes, and chromatography.
pH-sensitive polymer systems combined with nanotechnology could be utilized as an alternative strategy to traditional targeting systems to overcome major problems in current chemotherapy represented by non-specific tissue distribution of the drugs, tumor heterogeneity, and multidrug resistance (MDR) against anticancer drugs.
pH-sensitive polymer systems combined with nanotechnology could be utilized as an alternative strategy to traditional targeting systems to overcome major problems in current chemotherapy represented by non-specific tissue distribution of the drugs, tumor heterogeneity, and multidrug resistance (MDR) against anticancer drugs.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
pH-Responsive polymers
Kocak G, et al.
Polym. Chem., 8, 144-176 (2017)
pH-sensitive polymers for drug delivery.
Huh K M, et al.
Macromolecular Research, 20(3), 224-233 (2012)
Girish Kumar Tripathi et al.
Current drug delivery, 8(6), 667-677 (2012-02-09)
Helicobacter pylori reside in the gastric mucus layer and at the mucus-epithelial cell interface wherein access of antimicrobial drug to the infection site is restricted both from the stomach and from the gastric blood supply. The aim of the present
Prithankar Pramanik et al.
Macromolecular rapid communications, 37(18), 1499-1506 (2016-07-23)
The synthesis, micellar aggregation, and pH-triggered intracellular drug delivery ability of an amphiphilic statistical copolymer (P2) are studied. Two methacrylate derivatives, one containing a hydrophilic pendant and the other containing a hydrophobic pendant chain, are copolymerized to produce P2. The
Themis R Kyriakides et al.
Journal of controlled release : official journal of the Controlled Release Society, 78(1-3), 295-303 (2002-01-05)
Cytosolic delivery from endosomes is critical for those drugs that are susceptible to attack by lysosomal enzymes, such as DNA, RNA, oligonucleotides, proteins and peptides. Therefore, we have designed pH-sensitive, membrane-disruptive polymers to enhance the release of drugs from the
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