911550
Bis-MPA-RAFT dendrimer
trimethylol propane core, generation 1
别名:
CTA functionalized dendrimer, Multi-arm RAFT
产品名称
Bis-MPA-RAFT dendrimer, trimethylol propane core, generation 1
form
solid
mol wt
generation 1
no. Surface Groups
6
color
orange to red
storage temp.
−20°C
Application
Bis-MPA dendritic molecules are based on 2,2-bismethylolpropionicacid (bis-MPA) building blocks. The hydrolysable linkers presented in this type of polymers allow their degradation into byproducts that can be reabsorbed by the body or into excretable non-toxic small molecules. Therefore, this group of dendritic polymers is biocompatible and biodegradable, making them suitable for biomedical applications.
The corona of this product is functionalized with RAFT agents, which allow direct controlled polymerization from the dendrimer surface. It can be readily used to construct multi-arm polymer structure using suitable acrylic monomers.
The corona of this product is functionalized with RAFT agents, which allow direct controlled polymerization from the dendrimer surface. It can be readily used to construct multi-arm polymer structure using suitable acrylic monomers.
General description
- Polymer architecture: Dendrimer
- Generation: 1
- End Group Functionality: RAFT
- No. Surface Groups: 6
- Calculated Mol. Wt.: 2050.7 g/mol
- bis-MPA = 2,2-Bis(hydroxymethyl)propionic acid
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Chemistry of multifunctional polymers based on bis-MPA and their cutting-edge applications
Garcia-Gallego, S. et al.
Progress in Polymer Science, 48, 85-110 (2015)
Patrik Stenström et al.
Molecules (Basel, Switzerland), 23(8) (2018-08-17)
Herein, we present the first evaluation of cationic dendrimers based on 2,2-bis(methylol)propionic acid (bis-MPA) as nonviral vectors for transfection of short interfering RNA (siRNA) in cell cultures. The study encompassed dendrimers of generation one to four (G1⁻G4), modified to bear
Anna Carlmark et al.
Chemical Society reviews, 42(13), 5858-5879 (2013-05-01)
Dendritic polymers are highly branched, globular architectures with multiple representations of functional groups. These nanoscale organic frameworks continue to fascinate researchers worldwide and are today under intensive investigation in application-driven research. A large number of potential application areas have been
商品
Dendritic molecules' biomedical applications, particularly bis-MPA dendritic scaffolds, hold promise for drug delivery.
Dendrimers, polymer nanostructures, are synthesized for specific purposes by manipulating critical nanoscale design parameters (CNDPs).
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