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关于此项目
经验公式(希尔记法):
C29H40N3O8S4
化学文摘社编号:
分子量:
686.90
MDL number:
UNSPSC Code:
12352101
NACRES:
NA.22
产品名称
DMOTY TEA, ≥95%
SMILES string
COC1=CC=C2C(N(C(S2)=CC3=[N+](CCCS(=O)([O-])=O)C(C=C(OC)C=C4)=C4S3)CCCS(=O)([O-])=O)=C1.CCN(CC)CC
InChI
1S/C23H26N2O8S4.C6H15N/c1-32-16-5-7-20-18(13-16)24(9-3-11-36(26,27)28)22(34-20)15-23-25(10-4-12-37(29,30)31)19-14-17(33-2)6-8-21(19)35-23;1-4-7(5-2)6-3/h5-8,13-15H,3-4,9-12H2,1-2H3,(H-,26,27,28,29,30,31);4-6H2,1-3H3
InChI key
XGDLAZBMOHDWKV-UHFFFAOYSA-N
assay
≥95%
form
powder
storage temp.
−20°C
Quality Level
Application
DMOTY TEA is a thiacyanine-based fluorescent autophagy probe that localizes to lysosomes of live cells via selective binding to G-quadruplexes. DMOTY TEA will be a valuable tool for probing autophagy mechanisms and drug discovery research centering on protein degradation.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Hongbo Chen et al.
Chemical communications (Cambridge, England), 55(35), 5060-5063 (2019-03-26)
Monitoring autophagy can provide valuable insights into understanding human pathological mechanisms, developing novel drugs, and exploring autophagy control approaches. Here, we proposed a new strategy to specifically monitor autophagy by lighting up the G-quadruplex structures entering autolysosomes. Based on this
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