91862
三甲基（三氟甲基）硅烷 溶液
2 M in THF
别名:
(Trifluoromethyl)trimethylsilane, TFMTMS
登录 查看组织和合同定价。
选择尺寸
关于此项目
线性分子式:
(CH3)3SiCF3
化学文摘社编号:
分子量:
142.19
UNSPSC Code:
12352101
NACRES:
NA.22
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
4241868
产品名称
三甲基（三氟甲基）硅烷 溶液, 2 M in THF
InChI
1S/C4H9F3Si/c1-8(2,3)4(5,6)7/h1-3H3
SMILES string
C[Si](C)(C)C(F)(F)F
InChI key
MWKJTNBSKNUMFN-UHFFFAOYSA-N
form
liquid
reaction suitability
reaction type: C-C Bond Formation
IVD
for in vitro diagnostic use
concentration
2 M in THF
refractive index
n20/D 1.386
density
0.91 g/mL at 20 °C
functional group
fluoro
Quality Level
正在寻找类似产品? 访问 产品对比指南
Application
Reactant for:
- Silver-mediated C-H trifluoromethylation of arenes
- Preparation of trifluoromethyl ketone analog of L-arginine having contrasting inhibitory activity against human arginase I and histone deacetylase 8
- Organocatalyzed regio- and enantioselective allylic trifluoromethylation of Morita-Baylis-Hillman adducts
- Palladium-catalyzed oxidative trifluoromethylation of indoles
- Preparation of 5-HT1A antagonists
- Used as difluorocarbene source
TMSCF3 can be used as a reagent for:
It can also be used in trifluoromethylation of:
- Conversion of aromatic aldehydes to difluoromethylated products.
- C-H trifluoromethylation of arenes, terminal alkynes, tertiary amines, heteroarenes, allylic, and terminal alkenes using metal catalyst or metal free oxidative trifluoromethylation reaction.
It can also be used in trifluoromethylation of:
- Non-activated aldimines.
- Heterocumulenes.
- Azomethine imines.
General description
Trimethyl(trifluoromethyl)silane (TMSCF3) is also called as Ruppert-Prakash fluorination reagent. It is extensively used for the synthesis of trifluoromethyl-containing compounds.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3
target_organs
Respiratory system
supp_hazards
存储类别
3 - Flammable liquids
wgk
WGK 3
flash_point_f
1.4 °F
flash_point_c
-17 °C
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
危险化学品
此项目有
Trifluoromethylation of non-activated aldimines with trimethyl (trifluoromethyl) silane in the presence of tetramethylammonium fluoride: A closer look into the reaction route
Kirij NV, et al.
Journal of Fluorine Chemistry, 129(1), 14-21 (2008)
Recent advances in transition-metal-catalyzed trifluoromethylation and related transformations
Chen P and Liu G
Synthesis, 45(21), 2919-2939 (2013)
Catalytic enantioselective trifluoromethylation of azomethine imines with trimethyl (trifluoromethyl) silane
Kawai H, et al.
Angewandte Chemie (International Edition in English), 48(34), 6324-6327 (2009)
Oxidative trifluoromethylation and trifluoromethylthiolation reactions using (trifluoromethyl) trimethylsilane as a nucleophilic CF3 source
Chu L and Qing F-L
Accounts of Chemical Research, 47(5), 1513-1522 (2014)
Palladium-Catalyzed Oxidative Trifluoromethylation of Indoles at Room Temperature
Mu X, et al.
Chemistry?A European Journal , 17(22), 6039-6042 (2011)
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持