表单
viscous liquid (gel)
质量水平
杂质
<5 CFU/g Bioburden (Total Aerobic)
<5 CFU/g Bioburden (fungal)
<50 EU/mL Endotoxin
颜色
pale yellow to colorless
pH值（酸碱度）
6.5-7.5
粘度
10-40 cP(37 °C)
应用
3D bioprinting
储存温度
2-8°C
一般描述
Gelatin methacryloyl (GelMA) is a polymerizable hydrogel material derived from natural extracellular matrix (ECM) components. Due to its low cost, abundance, and retention of natural cell-binding motifs, gelatin has become a highly sought material for tissue engineering applications.
Alginate is a naturally occurring polymer widely applied for bioprinting applications as its printability can be easily modified by altering the polymer density and crosslinking with the addition of calcium chloride (CaCl2). Alginate is often combined with gelatin to facilitate cell adhesion and differentiation.
Temporal and spatial control of the crosslinking reaction can be obtained by adjusting the degree of functionalization and polymerization conditions, allowing for the fabrication of hydrogels with unique patterns, 3D structures, and morphologies.
Alginate is a naturally occurring polymer widely applied for bioprinting applications as its printability can be easily modified by altering the polymer density and crosslinking with the addition of calcium chloride (CaCl2). Alginate is often combined with gelatin to facilitate cell adhesion and differentiation.
Temporal and spatial control of the crosslinking reaction can be obtained by adjusting the degree of functionalization and polymerization conditions, allowing for the fabrication of hydrogels with unique patterns, 3D structures, and morphologies.
应用
Gelatin methacrylate based bioinks have been used in the following bioprinting applications:
- osteogenic ,
- chondrogenic ,
- hepatic ,
- adipogenic ,
- vasculogenic ,
- epithelial ,
- endothelial ,
- cardiac valve ,
- skin ,
- tumors
TissueFab® bioink Alg(Gel)ma -UV/365 nm, low endotoxin is a ready-to-use bioink which is formulated for low endotoxin levels, high cell viability, and printability and is designed for extrusion-based 3D bioprinting and subsequent 365 nm light and calcium chloride crosslinking. This bioink can be used with most extrusion-based bioprinters, are biodegradable, and are compatible with human mesenchymal stem cells (hMSCs) and other diverse cell types. TissueFab® bioink Alg(Gel)ma -UV/365 nm, low endotoxin enables the precise fabrication of 3D cell models and tissue constructs for research in 3D cell biology, tissue engineering, in vitro tissue models, and regenerative medicine.
特点和优势
- Ready-to-use formulation optimized for high printing fidelity and cell viability, eliminating the lengthy bioink formulation development process
- Step-by-step protocols developed and tested by MilliporeSigma 3D Bioprinting Scientists, no prior 3D bioprinting experience needed
- Suitable for different extrusion-based 3D bioprinter model
- Methacrylamide functional group can also be used to control the hydrogel physical parameters such as pore size, degradation rate, and swell ratio.
法律信息
TISSUEFAB is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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