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Merck
CN

933546

NanoFabTx - Natural Folate Lipid Mix

for synthesis of folate functionalized liposomes for targeted delivery

别名:

Cholesterol, EggPC, Folate-PEG-DSPE, PE-PEG

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关于此项目

NACRES:
NA.21
UNSPSC Code:
12352211
Storage temp.:
−20°C
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Quality Level

storage temp.

−20°C

Application

NanoFabTx Natural Folate Lipid Mix is a ready-to-use nanoformulation lipid mixture for the synthesis of folate-functionalized liposomes. This lipid mix enables users to encapsulate a wide variety of therapeutic drug molecules for targeted drug delivery applications without the need for lengthy trial-and-error optimization.
NanoFabTx Natural Folate Lipid Mix is a lyophilized, curated, lipid mixture containing rationally selected lipids in precise ratios that have been optimized to achieve liposomes of approximately 100nm in diameter. The synthesized folate-functionalized liposomes can be used to selectively target cells which overexpress folate receptors such as HeLa cells and delivery hydrophilic or hydrophobic drugs, including therapeutics that are thermo-sensitive.

Features and Benefits

  • A ready-to-use nanoformulation lipid blend for the synthesis of folate-functionalized liposomes without the need for high temepratures
  • Step-by-step protocols developed and tested by our formulation scientists
  • Flexible synthesis tool to create uniform and reproducible liposomes
  • Optimized to make liposomes around 100 nm with low polydispersity
  • Optimized lipid blend for folate-functionalized liposomes for therapeutic encapsulation
For microfluidic liposome synthesis of azide-functionalized liposomes, the NanoFabTx- Natural Folate Lipid Mix can be used with the the NanoFabTxMicrofluidic - nano device kit (Cat.No. 911593). The NanoFabTxMicrofluidic - nano device kit includes the microfluidics chips, fittings, and tubing required to get started with microfluidics-based synthesis (compatible microfluidics system or syringe pump required).

Legal Information

NANOFABTX is a trademark of Sigma-Aldrich Co. LLC


存储类别

11 - Combustible Solids

wgk

WGK 3

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相关内容


Mahmoud M Omar et al.
International journal of nanomedicine, 16, 683-700 (2021-02-05)
To develop an externally triggered rapid-release targeted system for treating ovarian cancer, gemcitabine (GMC) was entrapped into sonosensitive (SoS) folate (Fo)-modified liposomes (LPs). GMC-loaded LPs (GMC LPs), GMC-loaded Fo-targeted LPs (GMC-Fo LPs), and GMC-loaded Fo-targeted SoS LPs (GMC-SoS Fo LPs)
Ho Yub Yoon et al.
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Amit Verma et al.
Pharmaceutical research, 36(8), 123-123 (2019-06-21)
This investigation was aimed to explore the targeting potential of folate conjugated double liposomes (fDLs) bearing combination of synergistic drugs (Prednisolone and Methotrexate) for effective management of the rheumatoid arthritis (RA). To overcome the drawbacks of monotherapy, a combination of



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货号GTIN
933546-25MG-PW04065269098690
933546-100MG04065269098669
933546-25MG04065269098683
933546-100MG-PW04065269098676