NanoFabTx^™ - Synthetic Folate Lipid Mix

NanoFabTx^™ Synthetic Folate Lipid Mix is a ready-to-use nanoformulation lipid mixture for the synthesis of folate-functionalized liposomes. This lipid mix enables users to encapsulate a wide variety of therapeutic drug molecules for targeted drug delivery applications without the need for lengthy trial-and-error optimization.
The NanoFabTx^™ Synthetic Folate Lipid mix includes a lyophilized lipid blend containing rationally selected lipids that has been optimized to synthesize folate-functionalized liposomes of a desired size range. The synthesized folate-functionalized liposomes enable selectively targeting cells which overexpressed folate-receptors (e.g., HeLa cells) and delivery both hydrophilic and hydrophobic drugs.

• A ready-to-use nanoformulation lipid blend for the synthesis of folate-functionalized liposomes
• Step-by-step extrusion and microfluidics protocols developed and tested by our formulation scientists
• Flexible synthesis methods to create uniform and reproducible liposomes
• Protocols and lipid blend optimized to synthesize liposomes around 100 nm with low polydispersity
• Lipid mix optimized for folate-functionalized liposomes for small molecule encapsulation

Comprehensive protocols for liposome synthesis are included:

• A lipid film hydration and extrusion protocol
• A microfluidics protocol using commercial platforms or syringe pumps

The microfluidics protocol included with this product uses the NanoFabTx^™ device kit (911593). These kits come with the microfluidics chips, fittings, and tubing required to get started with microfluidics-based synthesis (compatible microfluidics system or syringe pump required).

NANOFABTX is a trademark of Sigma-Aldrich Co. LLC

TMAX is a trademark of Merck KGaA, Darmstadt, Germany