934372
MC-Val-Cit-PAB-PNP
≥95%
别名:
L-Ornithinamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]-
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关于此项目
经验公式（希尔记法）:
C35H43N7O11
化学文摘社编号:
分子量:
737.76
Beilstein/REAXYS Number:
10322169
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.22
MDL number:
Assay:
≥95%
Form:
powder
Quality Segment
assay
≥95%
form
powder
reaction suitability
reagent type: cross-linking reagent
storage temp.
2-8°C
SMILES string
[N+](=O)([O-])c1ccc(cc1)OC(=O)OCc2ccc(cc2)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CCCCCN3C(=O)C=CC3=O)C(C)C)CCCNC(=O)N
InChI key
HYSPJPGXSALJRR-DHIFEGFHSA-N
Application
This is a bifunctional cathepsin cleavable linker used in the construction of antibody drug conjugates (ADC).
Features and Benefits
The maleimide functionality can be used for bioconjugation to thiols in monoclonal antibodies while the activated carbonate esters can be used for construction of carbamate linkages with amine containing payloads.
存储类别
11 - Combustible Solids
怎么回事？
WGK 3
闪点 (F)
Not applicable
闪点 (°C)
Not applicable