934410
Carbamic acid, N-[2-(1-piperazinyl)ethyl]-, 1,1-dimethylethyl ester
≥95%
别名:
1,1-Dimethylethyl N-[2-(1-piperazinyl)ethyl]carbamate, 1-(2-((tert-Butoxycarbonyl)amino)ethyl)piperazine, tert-Butyl N-(2-(piperazin-1-yl)ethyl)carbamate, tert-Butyl [2-(piperazin-1-yl)ethyl]carbamate, Carbamic acid, [2-(1-piperazinyl)ethyl]-, 1,1-dimethylethyl ester
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关于此项目
经验公式（希尔记法）:
C11H23N3O2
化学文摘社编号:
分子量:
229.32
UNSPSC Code:
12352108
NACRES:
NA.21
MDL number:
Assay:
≥95%
Form:
powder
Quality Segment
assay
≥95%
form
powder
storage temp.
2-8°C
SMILES string
N1(CCNCC1)CCNC(=O)OC(C)(C)C
InChI
1S/C11H23N3O2/c1-11(2,3)16-10(15)13-6-9-14-7-4-12-5-8-14/h12H,4-9H2,1-3H3,(H,13,15)
InChI key
VPOIPCJBJNWHSJ-UHFFFAOYSA-N
Application
A functionalized cereblon ligand for development of Thalidomide based PROTACs. Allows rapid conjugation with carboxyl linkers due to presence of amine group via peptide coupling reactions. Amenable for linker attachement via reductive amination, and a basic building block for making protein degrader library.
Technology Spotlight:
Degrader Building Blocks for Targeted Protein Degradation
Protein Degrader Building Blocks
Technology Spotlight:
Degrader Building Blocks for Targeted Protein Degradation
Protein Degrader Building Blocks
Other Notes
Targeted Protein Degradation by Small Molecules
Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG
Small-Molecule PROTACS: New Approaches to Protein Degradation
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Impact of linker length on the activity of PROTACs
Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG
Small-Molecule PROTACS: New Approaches to Protein Degradation
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Impact of linker length on the activity of PROTACs
Legal Information
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable