产品名称
NanoFabTx™ Photoactivatable Lipid, redAzoPC
InChI
1S/C46H72Cl4N3O8P/c1-6-8-10-11-12-13-14-15-16-17-18-19-20-21-22-26-43(54)58-34-38(35-60-62(56,57)59-29-28-53(3,4)5)61-44(55)27-23-25-37-32-41(49)46(42(50)33-37)52-51-45-39(47)30-36(24-9-7-2)31-40(45)48/h30-33,38H,6-29,34-35H2,1-5H3/b52-51+/t38-/m1/s1
InChI key
FLGJQVLXMDITOI-MYZMGNDKSA-N
SMILES string
[O-]P(OCC[N+](C)(C)C)(OC[C@H](OC(CCCC1=CC(Cl)=C(C(Cl)=C1)/N=N/C2=C(C=C(C=C2Cl)CCCC)Cl)=O)COC(CCCCCCCCCCCCCCCCC)=O)=O
assay
≥90%
form
solid
color
orange to dark red
storage temp.
−20°C
Quality Level
Application
Lipid nanoparticle and liposome drug delivery systems
Features and Benefits
- Similar drug loading, encapsulation efficiency, size, and polydispersity to non-photoswitchable lipids
- Light-induced drug delivery
- Targeted and controlled release
- Overcomes limitations associated to UV-switchable lipids
General description
The NanoFabTx Photoactivatable Lipid, redAzoPC is a red-light photoswitchable lipid for controlled and targeted drug delivery. The tetra-ortho-chloro-azobenzene of redAzoPC can be isomerized from the cis to the trans conformation at 660 nm light. LNPs prepared using the NanoFabTx™ Photoactivatable Lipid, redAzoPC result in controlled drug release following deep red light irradiation.
Legal Information
NANOFABTX is a trademark of Sigma-Aldrich Co. LLC
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Johannes Morstein et al.
Chembiochem : a European journal of chemical biology, 22(1), 73-83 (2020-08-14)
Photoswitchable lipids are emerging tools for the precise manipulation and study of lipid function. They can modulate many aspects of membrane biophysics, including permeability, fluidity, lipid mobility and domain formation. They are also very useful in lipid physiology and enable
Tufan K Mukhopadhyay et al.
Current opinion in pharmacology, 63, 102202-102202 (2022-03-13)
Many aspects of cell signaling are controlled by lipids. Several signaling lipids have been functionalized with an azobenzene photoswitch to control underlying signaling dynamics with light. Herein, we provide an overview of signaling photolipids developed to date focusing on their
Nisha Chander et al.
Small (Weinheim an der Bergstrasse, Germany), 17(21), e2008198-e2008198 (2021-04-22)
Encapsulation of small molecule drugs in long-circulating lipid nanoparticles (LNPs) can reduce toxic side effects and enhance accumulation at tumor sites. A fundamental problem, however, is the slow release of encapsulated drugs from these liposomal systems at the disease site
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持