938335
Dibromomaleimide-BCN
≥95%
别名:
((1R,8S,9s)-bicyclo[6.1.0]non-4-yn-9-yl)methyl (2-(2-(2-(2-(3,4-dibromo-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetamido)ethoxy)ethoxy)ethyl)carbamate
InChI
InChI=1S/C23H29Br2N3O7/c24-19-20(25)22(31)28(21(19)30)13-18(29)26-7-9-33-11-12-34-10-8-27-23(32)35-14-17-15-5-3-1-2-4-6-16(15)17/h15-17H,3-14H2,(H,26,29)(H,27,32)/t15-,16+,17-
InChI key
WIDRVHOFRUPLME-BJWYYQGGSA-N
SMILES string
[H][C@@]1([C@@H]2COC(N([H])CCOCCOCCN([H])C(CN3C(C(Br)=C(Br)C3=O)=O)=O)=O)[C@@]2([H])CCC#CCC1
assay
≥95%
form
(Liquid or Semi-Solid or paste or solid)
color
colorless to yellow
storage temp.
−20°C
Quality Level
Application
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Optimised approach to albumin-drug conjugates using monobromomaleimide-C-2 linkers
Wall A, et al.
Organic & Biomolecular Chemistry, 17, 7870-7873 (2019)
Anders Dinesen et al.
Bioconjugate chemistry, 33(2), 333-342 (2022-02-08)
Albumin-nucleic acid biomolecular drug designs offer modular multifunctionalization and extended circulatory half-life. However, stability issues associated with conventional DNA nucleotides and maleimide bioconjugation chemistries limit the clinical potential. This work aims to improve the stability of this thiol conjugation and
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