A47052
6-氨基屈
95%
别名:
7-胺基去乙酰氧基头胞烷酸
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关于此项目
经验公式（希尔记法）:
C18H13N
化学文摘社编号:
分子量:
243.30
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
220-149-7
MDL number:
Assay:
95%
Form:
solid
InChI key
KIVUHCNVDWYUNP-UHFFFAOYSA-N
InChI
1S/C18H13N/c19-18-11-17-13-6-2-1-5-12(13)9-10-15(17)14-7-3-4-8-16(14)18/h1-11H,19H2
SMILES string
Nc1cc2c3ccccc3ccc2c4ccccc14
assay
95%
form
solid
mp
209-211 °C (lit.)
Quality Level
Application
诱发小鼠肿瘤。
signalword
Warning
hcodes
pcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
K B Delclos et al.
Carcinogenesis, 8(11), 1703-1709 (1987-11-01)
Since 6-nitrochrysene and 6-aminochrysene have shown activity in carcinogenicity bioassays, we have begun an investigation of their metabolic activation pathways and the nature of the carcinogen-DNA adducts that may be formed. N-Hydroxy-6-aminochrysene (N-hydroxy-AC), a candidate proximate or ultimate carcinogen and
M Mimura et al.
Drug metabolism and disposition: the biological fate of chemicals, 21(6), 1048-1056 (1993-11-01)
A cytochrome P-450 (P-450) enzyme of the CYP2B subfamily was partially purified from human liver microsomes and characterized with respect to immunochemical properties, N-terminal amino acid sequence, and catalytic activities toward typical P-450 substrates. P-450 enzymes were monitored in chromatographic
K B Delclos et al.
IARC scientific publications, (124)(124), 79-86 (1993-01-01)
Carcinogenic arylamines and nitroaromatic hydrocarbons are chemicals that present occupational health hazards and share pathways of metabolic activation. The 32P-postlabelled DNA adducts formed in Chinese hamster ovary (CHO) cells treated with metabolites from two pathways that are common to the
Determination of polycyclic aromatic amines in skin by liquid chromatography with electrochemical detection.
L J Felice et al.
Journal of chromatography, 354, 442-448 (1986-02-28)
H Yamazaki et al.
Carcinogenesis, 15(3), 465-470 (1994-03-01)
In order to address the hypothesis that 6-aminochrysene (6-AC) is converted to genotoxic products by cytochrome P450 enzymes via two activation pathways (N-hydroxylation and epoxidation), the activation of 6-AC and trans-1,2-dihydro-1,2-dihydroxy-6-aminochrysene (6-AC-diol) to genotoxic metabolites was examined in rat and
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