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A4926

1,2-双（2-氨基苯氧基）乙烷- N, N, N′, N′-四乙酸

Name: 1,2-双（2-氨基苯氧基）乙烷-<I> N, N, N′, N′</I>-四乙酸
Brand: ALDRICH

98%

别名:

2,2′-(亚乙二氧基)双苯胺-N,N,N′,N′-四乙酸, BAPTA, 亚乙二氧基双(邻亚苯基次氮基)四乙酸

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关于此项目

经验公式（希尔记法）:

C₂₂H₂₄N₂O₁₀

化学文摘社编号:

85233-19-8

分子量:

476.43

UNSPSC Code:

12352103

NACRES:

NA.23

PubChem Substance ID:

57653856

MDL number:

MFCD00036255

Beilstein/REAXYS Number:

5192406

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属性

assay

98%

form

powder

density

±1.494 g/cm³ at 25 °C (Predicted)

storage temp.

2-8°C

SMILES string

OC(=O)CN(CC(O)=O)c1ccccc1OCCOc2ccccc2N(CC(O)=O)CC(O)=O

InChI

1S/C22H24N2O10/c25-19(26)11-23(12-20(27)28)15-5-1-3-7-17(15)33-9-10-34-18-8-4-2-6-16(18)24(13-21(29)30)14-22(31)32/h1-8H,9-14H2,(H,25,26)(H,27,28)(H,29,30)(H,31,32)

InChI key

FTEDXVNDVHYDQW-UHFFFAOYSA-N

说明

General description

在自然界 1,2-双（2-氨基苯氧基）乙烷-N,N,N',N'四乙酸 (BAPTA) 是大鼠脑缺血神经保护剂 BAPTA-AM (BAPTA-tetra (actoxymethyl ester)) 的主要代谢产物。BAPTA 是一种细胞间 Ca ^{2 +} 螯合剂。

Application

The product can be used in various R&D applications such as:

Neuroscience: Used to suppress intracellular Ca²⁺ overload, reduce neuronal apoptosis, and preserve electrophysiological function in injury models, demonstrating strong neuroprotective action.

Pharmacology: Enables precise buffering of intracellular Ca²⁺ levels, allowing researchers to distinguish Ca²⁺‑ dependent drug effects and dissect therapeutic signaling mechanisms.

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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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商品

Sensor Dyes

Nitric oxide (NO) as a signal transporter in neurons, endothelial cells and in the immune system.

感应染料

一氧化氮 (NO) 是神经元、内皮细胞和免疫系统中的信号转运分子。

Determination of 1,2-bis (2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid (BAPTA free acid) in rat plasma, urine and feces by liquid chromatography with UV and tandem mass spectrometric detection.

Zheng Feng et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 878(30), 3052-3058 (2010-10-23)

BAPTA free acid was identified as the main metabolic product of 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid tetra(actoxymethyl ester) (BAPTA-AM), a neuroprotective agent in cerebral ischemia, in rats. In this paper, liquid chromatography-ultraviolet (LC-UV) and mass spectrometry/mass spectrometry (LC-MS/MS) methods were employed for the

Calcium rubies: a family of red-emitting functionalizable indicators suitable for two-photon Ca2+ imaging.

Mayeul Collot et al.

Journal of the American Chemical Society, 134(36), 14923-14931 (2012-07-24)

We designed Calcium Rubies, a family of functionalizable BAPTA-based red-fluorescent calcium (Ca(2+)) indicators as new tools for biological Ca(2+) imaging. The specificity of this Ca(2+)-indicator family is its side arm, attached on the ethylene glycol bridge that allows coupling the

1,2-bis(2-Aminophenoxy)ethane-N,N,N',N'-tetraacetic acid induces caspase-mediated apoptosis and reactive oxygen species-mediated necrosis in cultured cortical neurons.

K S Han et al.

Journal of neurochemistry, 78(2), 230-239 (2001-07-20)

Sustained alteration in [Ca(2+)]i triggers neuronal death. We examined morphological and signaling events of Ca(2+)-deficiency-induced neuronal death. Cortical cell cultures exposed to 20 microM 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid (BAPTA-AM), an intracellular calcium chelator, underwent neuronal apoptosis within 12 h that was evident

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全球贸易项目编号

货号	GTIN
A4926-1G	04061833375235
A4926-250MG	04061833375242
A4926-5G	04061833425930