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A50606

6-氨基尿嘧啶

Name: 6-氨基尿嘧啶
Brand: ALDRICH

97%

别名:

4-氨基-2,6-二羟基嘧啶, 6-氨基-2,4-嘧啶二醇

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关于此项目

经验公式（希尔记法）:

C₄H₅N₃O₂

化学文摘社编号:

873-83-6

分子量:

127.10

UNSPSC Code:

12352100

NACRES:

NA.22

PubChem Substance ID:

24890937

EC Number:

212-854-3

Beilstein/REAXYS Number:

120491

MDL number:

MFCD00006071

Assay:

97%

Form:

powder

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属性

Quality Level

100

assay

97%

form

powder

mp

≥360 °C (lit.)

SMILES string

Nc1cc(O)nc(O)n1

InChI

1S/C4H5N3O2/c5-2-1-3(8)7-4(9)6-2/h1H,(H4,5,6,7,8,9)

InChI key

LNDZXOWGUAIUBG-UHFFFAOYSA-N

说明

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Thymidine phosphorylase inhibitors: recent developments and potential therapeutic applications.

María-Jesús Pérez-Pérez et al.

Mini reviews in medicinal chemistry, 5(12), 1113-1123 (2005-12-27)

Thymidine Phosphorylase (TPase) catalyses the reversible phosphorolysis of pyrimidine 2'-deoxynucleosides to 2-deoxyribose-1-phosphate and their respective pyrimidine bases, including the phosphorolysis of nucleoside analogues with important antiviral or anticancer properties. Moreover, TPase, identified also as the angiogenic platelet-derived endothelial cell growth

Synthesis, chemical and pharmacological properties of some 2,4-dioxo-1,2,3,4,5,6,7,8-octahydropyrimido [4,5-d]pyrimidines.

H Sladowska et al.

Acta poloniae pharmaceutica, 53(1), 39-46 (1996-01-01)

Synthesis of 6-substituted 2,4-dioxo-1,2,3,4,5,6,7,8-octahydropyrimido[4,5-d]pyrimidines [III-VI] obtained by cyclocondensation of 1-phenyl-6-aminouracil with formaline and the primary amines is described. Compounds III, V, VI in the Mannich reaction with secondary cyclic amines yield the corresponding 3-substituted N-aminomethyl derivatives VII-X. Some of them

6-Anilinouracil-based inhibitors of Bacillus subtilis DNA polymerase III: antipolymerase and antimicrobial structure-activity relationships based on substitution at uracil N3.

P M Tarantino et al.

Journal of medicinal chemistry, 42(11), 2035-2040 (1999-06-04)

6-Anilinouracils (6-AUs) are dGTP analogues which selectively inhibit the DNA polymerase III of Bacillus subtilis and other Gram-positive bacteria. To enhance the potential of the 6-AUs as antimicrobial agents, a structure-activity relationship was developed involving substitutions of the uracil N3

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全球贸易项目编号

货号	GTIN
A50606-100G	04061838352279