A59654
5-氨基吲哚
97%
别名:
5-吲哚胺
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关于此项目
经验公式（希尔记法）:
C8H8N2
化学文摘社编号:
分子量:
132.16
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
225-977-2
Beilstein/REAXYS Number:
112348
MDL number:
产品名称
5-氨基吲哚, 97%
InChI key
ZCBIFHNDZBSCEP-UHFFFAOYSA-N
InChI
1S/C8H8N2/c9-7-1-2-8-6(5-7)3-4-10-8/h1-5,10H,9H2
SMILES string
Nc1ccc2[nH]ccc2c1
assay
97%
form
crystals
mp
131-133 °C (dec.) (lit.)
Quality Level
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Application
Reactant for preparation of:
- Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP
- Cytotoxic and antimitotic agents
- Insulin-like growth factor 1 receptor inhibitors
- Antitumoral agents
- Factor Xa inhibitor
- Potential antivascular agents
- Gli1-mediated transcription in the Hedgehog pathway
- Inhibitors of receptor tyrosine kinase with antiangiogenic effects
- PKCθ inhibitors
- HIV protease inhibitors
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Aquatic Acute 1 - Eye Irrit. 2
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Michael Jakun Koo et al.
Biochemical and biophysical research communications, 464(3), 875-880 (2015-07-19)
Cellular metabolism can impact cell life or death outcomes. While metabolic dysfunction has been linked to cell death, the mechanisms by which metabolic dysfunction regulates the cell death mode called necroptosis remain unclear. Our study demonstrates that mitochondrial oxidative phosphorylation
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