A76109
3-氨基-1-丙磺酸
97%
别名:
3-氨基丙烷磺酸, 3APS, 高牛磺酸
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关于此项目
线性分子式:
H2N(CH2)3SO3H
化学文摘社编号:
分子量:
139.17
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
222-977-4
MDL number:
Assay:
97%
Form:
solid
InChI key
SNKZJIOFVMKAOJ-UHFFFAOYSA-N
InChI
1S/C3H9NO3S/c4-2-1-3-8(5,6)7/h1-4H2,(H,5,6,7)
SMILES string
NCCCS(O)(=O)=O
assay
97%
form
solid
mp
293 °C (dec.) (lit.)
Quality Level
Application
重要的 GABA-mimetic 药物成分，可引起类似于 γ-氨基丁酸 (GABA) 诱导的神经反应。
存储类别
13 - Non Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
D Saumier et al.
The journal of nutrition, health & aging, 13(9), 808-812 (2009-10-09)
Tramiprosate (homotaurine, ALZHEMEDTM) was recently investigated for its efficacy, safety and disease-modification effects in a Phase III clinical study in mild to moderate Alzheimer's disease (AD) patients (the Alphase study). The primary cognitive endpoint measure of that study was the
S Gauthier et al.
The journal of nutrition, health & aging, 13(6), 550-557 (2009-06-19)
The efficacy, safety and disease-modification of tramiprosate (homotaurine)were investigated in a recently completed large-scale Phase III clinical study in patients with mild to moderate Alzheimer's disease (AD), the Alphase study. Disease-modification was assessed using longitudinal volumetric MRI (vMRI) measurements of
J Y Wu et al.
Journal of biomedical science, 8(1), 96-103 (2001-02-15)
Acamprosate (AC), N-acetyl-homotaurine, has recently been introduced for treating alcohol craving and reducing relapses in weaned alcoholics. AC may exert its action through the taurine system rather than the glutamatergic or GABAergic system. This conclusion is based on the observations
R Nageswara Rao et al.
Journal of pharmaceutical and biomedical analysis, 55(2), 282-287 (2011-02-18)
Alzheimer disease (AD) is characterized pathologically by extracellular amyloid deposits composed of amyloid β (Aβ) protein. A simple and rapid method using HPLC with fluorescence detector was developed and validated for determination of tramiprosate in rat plasma. Pre-column derivatization of
Eric Martineau et al.
Journal of the American Society for Mass Spectrometry, 21(9), 1506-1514 (2010-06-29)
This paper describes an efficient and reproducible screening method for identifying low molecular weight compounds that bind to amyloid beta peptides (Abeta) peptides using electrospray ionization mass spectrometry (ESI-MS). Low molecular weight compounds capable of interacting with soluble Abeta may
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