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Merck
CN

CDS022564

厄洛替尼盐酸盐

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经验公式(希尔记法):
C22H24ClN3O4
化学文摘社编号:
分子量:
429.90
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
NACRES:
NA.21
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InChI

1S/C22H23N3O4.ClH/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22;/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25);1H

SMILES string

C#CC1=CC(NC2=NC=NC3=CC(OCCOC)=C(OCCOC)C=C32)=CC=C1.Cl

InChI key

GTTBEUCJPZQMDZ-UHFFFAOYSA-N

description

AldrichCPR

form

solid

Gene Information

human ... EGFR(1956)

General description

酸厄洛替尼是一种强效表皮生长因子受体(EGFR)酪氨酸激酶抑制剂。它抑制EGFR蛋白,这可能有助于预防癌细胞的生长。它还可与盐酸吉西他滨一起使用。

Other Notes

请注意,Sigma-Aldrich将此产品作为一系列独特化学品的一部分提供给早期发现的研究人员。Sigma-Aldrich不会收集该产品的分析数据。买方承担确认产品标识和纯度的责任。所有销售均为最终销售。

尽管SIGMA-ALDRICH的标准条款和条件以及SIGMA-ALDRICH和买方之间的协议中包含所有合同条款,但无论是在法律、交易过程、执行过程中的行为、以及贸易或其他方面的使用等过程中,SIGMA-ALDRICH按“原样”销售此产品并且并对此产品不作任何陈述或担保,包括:(A)适销性担保;(B)特定用途适用性担保;或(C)未侵犯第三方知识产权担保。

pictograms

Skull and crossbones

signalword

Danger

hcodes

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Chronic 4

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Osamu Yasumuro et al.
Xenobiotica; the fate of foreign compounds in biological systems, 48(11), 1106-1112 (2017-10-24)
1. Although drug interactions between epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) and gastric acid-suppressing medications (AS) are considered clinically significant, there is limited data regarding the influence of various gastric pH conditions on the pharmacokinetics of EGFR-TKIs. We aimed
Ofer Shamni et al.
Molecular imaging and biology, 21(4), 696-704 (2018-11-01)
Positron emission tomography (PET) using [11C]erlotinib identifies non-small cell lung carcinoma (NSCLC) tumors with activating mutations in the epidermal growth factor receptor (EGFRm). The short half-life of C-11, however, limits its clinical utility to centers with a nearby cyclotron. We
Nicolas Tournier et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 58(1), 117-122 (2016-08-06)
The tyrosine kinase inhibitor erlotinib poorly penetrates the blood-brain barrier (BBB) because of efflux transport by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2), thereby limiting its utility in the treatment of non-small cell lung cancer metastases in the brain.
Valentina Fustaino et al.
Oncotarget, 8(61), 103340-103363 (2017-12-22)
Increasing evidence points to a key role played by epithelial-mesenchymal transition (EMT) in cancer progression and drug resistance. In this study, we used
Yoshitaro Heshiki et al.
Microbiome, 8(1), 28-28 (2020-03-07)
The gut microbiota has the potential to influence the efficacy of cancer therapy. Here, we investigated the contribution of the intestinal microbiome on treatment outcomes in a heterogeneous cohort that included multiple cancer types to identify microbes with a global

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