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Merck
CN

CDS023389

达沙替尼

别名:

N-(2-氯-6-甲基苯基)-2-[[6-[4-(2-羟乙基)-1-哌嗪基]-2-甲基-4-嘧啶基]氨基]-5-噻唑甲酰胺

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关于此项目

经验公式(希尔记法):
C22H26ClN7O2S
化学文摘社编号:
分子量:
488.01
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
NACRES:
NA.21
Form:
solid
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description

AldrichCPR

form

solid

storage temp.

-10 to -25°C

SMILES string

CC1=NC(NC2=NC=C(C(NC3=C(C=CC=C3Cl)C)=O)S2)=CC(N4CCN(CC4)CCO)=N1

InChI

1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27)

InChI key

ZBNZXTGUTAYRHI-UHFFFAOYSA-N

Other Notes

请注意,Sigma-Aldrich 向早期发现研究人员提供该产品,作为独特化学品集合的一部分。Sigma-Aldrich 不收集本品的分析数据。买方负责确认产品标识和/或纯度。所有销售均为最终产品。

尽管 SIGMA-ALDRICH 中包含任何违反条款的条款和标准条款和条件以及 SIGMA-ALDRICH 与买方之间的协议,但 SIGMA-ALDRICH “按原样”销售本产品,且不对本产品做出任何声明或保证,包括任何 (A) 适销性保证;(B) 对某一特定用途的适合性的保证;(C) 防止侵犯第三方知识产权的保证;无论侵犯活动是由法律、交易过程、履行过程、贸易惯例还是其他原因引起的。


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signalword

Danger

Hazard Classifications

Aquatic Chronic 1 - Carc. 2 - Eye Dam. 1 - Repr. 2 - Skin Irrit. 2 - STOT RE 1

target_organs

Gastro-intestinal system

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Maja Kim Kuepper et al.
Leukemia, 33(8), 1964-1977 (2019-03-08)
Tyrosine kinase inhibitor (TKI) therapy effectively blocks oncogenic Bcr-Abl signaling and induces molecular remission in the majority of CML patients. However, the disease-driving stem cell population is not fully targeted by TKI therapy in the majority of patients, and leukemic
Kenta Mukaihara et al.
PloS one, 12(9), e0185321-e0185321 (2017-09-26)
Alveolar soft part sarcoma (ASPS) is an extremely rare metastatic soft tissue tumor with a poor prognosis for which no effective systemic therapies have yet been established. Therefore, the development of novel effective treatment approaches is required. Tyrosine kinases (TKs)
Lei Liu et al.
Journal of pineal research, 67(2), e12588-e12588 (2019-05-30)
Chordoma is an extremely rare malignant bone tumor with a high rate of relapse. While cancer stem cells (CSCs) are closely associated with tumor recurrence, which depend on its capacity to self-renew and induce chemo-/radioresistance, whether and how CSCs participate



全球贸易项目编号

货号GTIN
CDS023389-25MG04061829045289