质量水平
方案
98%
表单
crystals
mp
167-169 °C (dec.) (lit.)
SMILES字符串
Cl[H].Cl[H].CNNC
InChI
1S/C2H8N2.2ClH/c1-3-4-2;;/h3-4H,1-2H3;2*1H
InChI key
WLDRFJDGKMTPPV-UHFFFAOYSA-N
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生化/生理作用
可诱导大鼠和小鼠患结肠癌。
警示用语:
Danger
危险分类
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Chronic 2 - Carc. 1B
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
个人防护装备
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Hisako Hori et al.
Regulatory toxicology and pharmacology : RTP, 112, 104578-104578 (2020-01-15)
Genotoxicity occurring at the target organs of carcinogenesis is important for understanding the mechanisms of chemical carcinogenicity and also for setting of threshold estimation. In vivo gene mutations have been evaluated by transgenic animal models in which any organ can
Preety Ghanghas et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 78, 239-247 (2016-02-24)
Non-steroidal anti-inflammatory drugs (NSAIDs) are emerging as novel chemopreventive agents against a variety of cancers owing to their capability in blocking the tumor development by cellular proliferation and by promoting apoptosis. Inflammation is principal cause of colon carcinogenesis. A missing
Vijay L Kumar et al.
Drug development research, 80(8), 1089-1097 (2019-09-01)
Anti-inflammatory drugs are well known to reduce the risk of colon cancer and prophylactic use of such agents is gaining acceptance as a cancer prevention therapy. As artesunate, an antimalarial drug, has been shown to exhibit chemopreventive properties, the present
Reema Narayan et al.
Carbohydrate polymers, 261, 117893-117893 (2021-03-27)
Glycosylated pH-sensitive mesoporous silica nanoparticles (MSNs) of capecitabine (CAP) were developed for targeting colorectal cancer. The MSNs possessed an average pore diameter of 8.12 ± 0.43 nm, pore volume of 0.73 ± 0.21 cm3/g, and particle size of 245.24 ±
Leila Kaeid Sharaf et al.
Nutrition and cancer, 70(6), 946-955 (2018-09-06)
Epidemiological and experimental observations have shown that nonsteroidal anti-inflammatory drugs especially selective cyclooxygenase-2 (COX-2) inhibitors and probiotics reduce the incidence risk of colon cancer. Therefore, the present study was designed to assess the prophylactic potentials of probiotics (Lactobacillus acidophilus and
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Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete.
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