D26202
3,5-二氨基-1,2,4-三氮唑
98%
别名:
胍唑
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关于此项目
经验公式（希尔记法）:
C2H5N5
化学文摘社编号:
分子量:
99.09
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
215-937-2
Beilstein/REAXYS Number:
112467
MDL number:
Assay:
98%
Form:
solid
InChI
1S/C2H5N5/c3-1-5-2(4)7-6-1/h(H5,3,4,5,6,7)
InChI key
PKWIYNIDEDLDCJ-UHFFFAOYSA-N
SMILES string
Nc1n[nH]c(N)n1
assay
98%
form
solid
Quality Level
General description
3,5-二氨基-1,2,4-三唑，别名胍唑，是杂环化合物，常作为合成砌块制备叔丁基取代无环和环状化合物的镓络合物。也用作铜的缓蚀剂。
Application
DNA 合成抑制剂。
signalword
Warning
hcodes
Hazard Classifications
Aquatic Chronic 2 - Repr. 2 - STOT RE 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
T Spector et al.
The Journal of biological chemistry, 260(15), 8694-8697 (1985-07-25)
Several known inhibitors of mammalian ribonucleotide reductase were studied for their interactions with herpes simplex virus type 1 (HSV-1) ribonucleotide reductase. MAIQ (4-methyl-5-amino-1-formylisoquinoline thiosemicarbazone) produced apparent inactivation of HSV-1 ribonucleotide reductase. Only catalytically cycling, not resting, enzyme could be inactivated.
R G Hards et al.
Canadian journal of biochemistry and cell biology = Revue canadienne de biochimie et biologie cellulaire, 61(2-3), 120-129 (1983-02-01)
N-Carbamoyloxyurea is cytotoxic for cells in culture and, like hydroxyurea and guanazole, the drug is an effective inhibitor of mammalian ribonucleotide reductase and thus DNA synthesis. In addition to ribonucleotide reductase, N-carbamoyloxyurea has a second site of action which also
G R Gale et al.
Cancer treatment reports, 63(3), 449-456 (1979-03-01)
Each of three ribonucleoside diphosphate reductase inhibitors was used as a third drug in combination with selected antitumor platinum (Pt) agents and cyclophosphamide (CY) in the treatment of advanced L1210 leukemia in C57BL/6 x DBA/2 mice. Each was synergistic with
Effect of iron-chelating agents on inhibitors of ribonucleotide reductase.
J G Cory et al.
Biochemical pharmacology, 30(9), 979-984 (1981-05-01)
Guanazole in the treatment of advanced bronchogenic carcinoma: a pilot study of the Southeastern Cancer Study Group.
S Krauss et al.
Cancer treatment reports, 70(7), 913-914 (1986-07-01)
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