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D26202

3,5-二氨基-1,2,4-三氮唑

Name: 3,5-二氨基-1,2,4-三氮唑
Brand: ALDRICH

98%

别名:

胍唑

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关于此项目

经验公式（希尔记法）:

C₂H₅N₅

化学文摘社编号:

1455-77-2

分子量:

99.09

UNSPSC Code:

12352100

NACRES:

NA.22

PubChem Substance ID:

24893699

EC Number:

215-937-2

Beilstein/REAXYS Number:

112467

MDL number:

MFCD00005233

Assay:

98%

Form:

solid

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属性

Quality Level

200

assay

98%

form

solid

mp

202-205 °C (lit.)

SMILES string

Nc1n[nH]c(N)n1

InChI

1S/C2H5N5/c3-1-5-2(4)7-6-1/h(H5,3,4,5,6,7)

InChI key

PKWIYNIDEDLDCJ-UHFFFAOYSA-N

说明

General description

3,5-二氨基-1,2,4-三唑，别名胍唑，是杂环化合物，常作为合成砌块制备叔丁基取代无环和环状化合物的镓络合物。也用作铜的缓蚀剂。

Application

DNA 合成抑制剂。

pictograms

GHS08,GHS09

signalword

Warning

hcodes

H361fd,H373,H411

pcodes

P202 - P260 - P273 - P280 - P308 + P313 - P391

Hazard Classifications

Aquatic Chronic 2 - Repr. 2 - STOT RE 2

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Schedule-dependency assessments of ribonucleoside diphosphate reductase inhibitors when used in combination with platinum compounds plus cyclophosphamide in the treatment of advanced L1210 leukemia.

G R Gale et al.

Cancer treatment reports, 63(3), 449-456 (1979-03-01)

Each of three ribonucleoside diphosphate reductase inhibitors was used as a third drug in combination with selected antitumor platinum (Pt) agents and cyclophosphamide (CY) in the treatment of advanced L1210 leukemia in C57BL/6 x DBA/2 mice. Each was synergistic with

A series of N-carbamoyloxyurea resistant cell lines with alterations in ribonucleotide reductase: lack of coordination in pyrimidine and purine reductase activity.

R G Hards et al.

Canadian journal of biochemistry and cell biology = Revue canadienne de biochimie et biologie cellulaire, 61(2-3), 120-129 (1983-02-01)

N-Carbamoyloxyurea is cytotoxic for cells in culture and, like hydroxyurea and guanazole, the drug is an effective inhibitor of mammalian ribonucleotide reductase and thus DNA synthesis. In addition to ribonucleotide reductase, N-carbamoyloxyurea has a second site of action which also

Effect of iron-chelating agents on inhibitors of ribonucleotide reductase.

J G Cory et al.

Biochemical pharmacology, 30(9), 979-984 (1981-05-01)

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全球贸易项目编号

货号	GTIN
D26202-100G	04061838353856
D26202-25G	04061833562444