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Merck
CN

D7631

Sigma-Aldrich

5,5-二甲基噁唑烷-2,4-二酮

别名:

DMO, NSC 30152, 二甲双酮

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关于此项目

经验公式(希尔记法):
C5H7NO3
化学文摘社编号:
分子量:
129.11
EC 号:
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22
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表单

powder

mp

77-80 °C (lit.)

储存温度

2-8°C

SMILES字符串

CC1(C)OC(=O)NC1=O

InChI

1S/C5H7NO3/c1-5(2)3(7)6-4(8)9-5/h1-2H3,(H,6,7,8)

InChI key

JYJFNDQBESEHJQ-UHFFFAOYSA-N

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应用

作为反应物,参与以下反应:
  • 苯并环镍或萘环镍β氧杂氮杂氯配合物的合成
  • 用作组织蛋白酶K抑制剂

参与药理学研究的分子包括:
  • 抗癫痫药生物等效仿制药的鉴定
  • 筛选将能量代谢从线粒体呼吸转变为糖酵解的药物
  • 溶解总胆管囊肿/胰胆管连接不良患者的蛋白塞

象形图

Health hazardExclamation mark

警示用语:

Warning

危险分类

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Shin Yoshitake et al.
Diabetologia, 62(3), 504-516 (2018-11-30)
In diabetic macular oedema (DMO), blood components passing through the disrupted blood-retinal barrier cause neuroinflammation, but the mechanism by which autoantibodies induce neuroglial dysfunction is unknown. The aim of this study was to identify a novel autoantibody and to evaluate
S E Andersson et al.
The Journal of rheumatology, 26(9), 2018-2024 (1999-09-24)
To measure intracellular and tissue pH in periarticular soft tissue during different phases of antigen induced arthritis in the rat. pH was calculated using the following values: (1) the distribution of [14C]-dimethyl-oxazolidinedione; (2) the total tissue water and the extracellular
Anne C Biechl et al.
Clinical & experimental ophthalmology, 48(6), 802-812 (2020-05-10)
Evaluating the treatment outcomes of diabetic macular oedema (DMO) in routine clinical practice provides data for comparison with those of clinical trials. Phase 3 clinical trials of vascular endothelial growth factor (VEGF) inhibitors for DMO have reported significant improvements in
D P Nolan et al.
European journal of biochemistry, 267(15), 4601-4614 (2000-07-21)
Conditions for the use of both [14C]methylamine and 5, 5-dimethyl[14C]oxa-azolidine-2,4-dione (DMO) to measure the H+ concentration of intracellular compartments of monomorphic long thin bloodstream forms of Trypanosoma brucei were established. Neither probe was actively transported or bound to internal components
D P Nolan et al.
European journal of biochemistry, 267(1), 18-27 (1999-12-22)
Natural infections of mammals with African trypanosomes, such as Trypanosoma brucei, are generally pleomorphic, the population consisting of different forms, termed slender and stumpy forms, that vary in number as the parasitaemia develops. We show that the differentiation of slender

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