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Merck
CN

D7631

5,5-二甲基噁唑烷-2,4-二酮

别名:

DMO, NSC 30152, 二甲双酮

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关于此项目

经验公式(希尔记法):
C5H7NO3
化学文摘社编号:
分子量:
129.11
EC 号:
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22
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表单

powder

质量水平

mp

77-80 °C (lit.)

储存温度

2-8°C

SMILES字符串

CC1(C)OC(=O)NC1=O

InChI

1S/C5H7NO3/c1-5(2)3(7)6-4(8)9-5/h1-2H3,(H,6,7,8)

InChI key

JYJFNDQBESEHJQ-UHFFFAOYSA-N

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应用

作为反应物,参与以下反应:
  • 苯并环镍或萘环镍β氧杂氮杂氯配合物的合成
  • 用作组织蛋白酶K抑制剂

参与药理学研究的分子包括:
  • 抗癫痫药生物等效仿制药的鉴定
  • 筛选将能量代谢从线粒体呼吸转变为糖酵解的药物
  • 溶解总胆管囊肿/胰胆管连接不良患者的蛋白塞

象形图

Health hazardExclamation mark

警示用语:

Warning

危险分类

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Cunxi Wang et al.
Regulatory toxicology and pharmacology : RTP, 81, 171-182 (2016-10-30)
Dicamba tolerant (DT) soybean, cotton and maize were developed through constitutive expression of dicamba mono-oxygenase (DMO) in chloroplasts. DMO expressed in three DT crops exhibit 91.6-97.1% amino acid sequence identity to wild type DMO. All DMO forms maintain the characteristics
Jingxuan Wang et al.
Food & function, 10(8), 4823-4833 (2019-07-19)
Donkey milk is considered to be a valuable nutritional source. Deeper knowledge of the constituents of donkey milk is necessary. As multifunctional components of milk, oligosaccharides have been reported to have the potential to support intestine development. We studied the
D P Nolan et al.
European journal of biochemistry, 267(15), 4601-4614 (2000-07-21)
Conditions for the use of both [14C]methylamine and 5, 5-dimethyl[14C]oxa-azolidine-2,4-dione (DMO) to measure the H+ concentration of intracellular compartments of monomorphic long thin bloodstream forms of Trypanosoma brucei were established. Neither probe was actively transported or bound to internal components
Christian Danielsson et al.
Birth defects research. Part A, Clinical and molecular teratology, 79(8), 595-603 (2007-06-23)
The antiepileptic drugs (AEDs) phenytoin, phenobarbital, dimethadione, and carbamazepine cause a similar pattern of malformations in humans, with an increased risk after polytherapy. The teratogenicity has been linked to cardiac rhythm disturbances and hypoxic damage as a consequence of their
Hemal Mehta et al.
The British journal of ophthalmology, 102(4), 479-482 (2017-08-06)
To determine whether early vision gains predict long-term visual outcomes in the BEVORDEX randomised clinical trial of bevacizumab or dexamethasone implants for diabetic macular oedema. Post hoc analysis of 68 study eyes (77%) that completed 2 years follow-up of the

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