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Merck
CN

D9754

2-氨乙基二苯基硼酸盐

97%

别名:

2-APB, 2-氨基乙基二苯基硼酸酯, 2-氨基乙基联苯基硼酸酯, NSC 17107, 二苯基硼酸, 二苯基硼酸 2-氨基乙酯

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关于此项目

线性分子式:
(C6H5)2BOCH2CH2NH2
化学文摘社编号:
分子量:
225.09
UNSPSC Code:
12352103
NACRES:
NA.22
PubChem Substance ID:
EC Number:
208-366-5
Beilstein/REAXYS Number:
2942273
MDL number:
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产品名称

2-氨乙基二苯基硼酸盐, 97%

InChI

1S/C14H16BNO/c16-11-12-17-15(13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-10H,11-12,16H2

InChI key

BLZVCIGGICSWIG-UHFFFAOYSA-N

SMILES string

NCCOB(c1ccccc1)c2ccccc2

description

Drug Control: Új pszichoaktív anyag / New psychoactive substance (Hungary), 78/2022. (XII. 28.) BM rendelet

assay

97%

form

powder

drug control

Új pszichoaktív anyag / New psychoactive substance (Hungary), 78/2022. (XII. 28.) BM rendelet

storage temp.

−20°C

Quality Level

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Application

可用作以下反应试剂:
  • 制备细胞凋亡诱导剂

  • Orai3(ORAI钙释放-激活钙调节因子3)蛋白活化剂
  • 抑制大鼠背根神经节神经元通过瞬时受体电位2通道的Ca2+
  • 膜渗透SOCE(库调控钙入口)抑制剂

Biochem/physiol Actions

用于细胞内 IP3 诱导钙释放的膜渗透性调节剂。

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Akinobu Z Suzuki et al.
Bioorganic & medicinal chemistry letters, 20(4), 1395-1398 (2010-01-26)
Store-operated calcium entry (SOCE) is an important mechanism for replenishing intracellular calcium stores and for sustaining calcium signaling. We developed a method for synthesis of bisboron compounds that have two borinic acids or their esters in one molecule. These compounds
Velasco-Bejarano, B.; et al.
Synlett, 921-921 (2007)
T Maruyama et al.
Journal of biochemistry, 122(3), 498-505 (1997-11-05)
The effects of a novel membrane-penetrable modulator, 2APB (2-aminoethoxy diphenyl borate), on Ins(1,4,5)P3-induced Ca2+ release were examined. 2APB inhibited Ins(1,4,5)P3-induced Ca2+ release from rat cerebellar microsomal preparations without affecting [3H]Ins(1,4,5)P3 binding to its receptor. The IC50 value (concentration producing 50%
Mustafa Nazıroğlu et al.
The Journal of membrane biology, 241(2), 69-75 (2011-04-22)
Exposure to oxidative stress causes health problems, including sensory neuron neuropathy and pain. Rotenone is a toxin used to generate intracellular oxidative stress in neurons. However, the mechanism of toxicity in dorsal root ganglion (DRG) neurons has not been characterized.
Judith Bergsmann et al.
The Journal of biological chemistry, 286(36), 31565-31575 (2011-07-05)
STIM1 and Orai represent the key components of Ca(2+) release-activated Ca(2+) channels. Activation of Orai channels requires coupling of the C terminus of STIM1 to the N and C termini of Orai. Although the latter appears to be central in

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