亚磷酸二乙酯

Name: 亚磷酸二乙酯
Brand: ALDRICH

98%

别名:

Diethoxyphosphine oxide, Diethyl acid phosphite, Diethyl hydrogen phosphite, Diethyl phosphonate, Hydrogen diethyl phosphite

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所有图片(1)

About This Item

线性分子式:

(C₂H₅O)₂P(O)H

CAS Number:

762-04-9

分子量:

138.10

Beilstein:

605759

EC 号:

212-091-6

MDL编号:

MFCD00044573

UNSPSC代码:

12352100

PubChem化学物质编号:

24894335

NACRES:

NA.22

质量水平

200

方案

98%

表单

liquid

折射率

n20/D 1.407 (lit.)

沸点

50-51 °C/2 mmHg (lit.)

密度

1.072 g/mL at 25 °C (lit.)

SMILES字符串

[H]P(=O)(OCC)OCC

InChI

1S/C4H11O3P/c1-3-6-8(5)7-4-2/h8H,3-4H2,1-2H3

InChI key

MJUJXFBTEFXVKU-UHFFFAOYSA-N

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一般描述

Diethyl phosphite is the organophosphorus compound used as a phosphorylating agent in organic synthesis.

应用

Applications of diethyl phosphite (DEP):

It can undergo condensation with aldehydes or ketones and an amine to form α-aminophosphonates under solvent-free and catalyst-free conditions.
Reduction of gem-dibromo derivatives using diethyl phosphite in the presence of triethylamine gives monobromocyclopropanes.
Along with 4-dimethylaminopyridine, it can be used as a ligand for nickel-catalyzed cross-coupling of aryl and heteroaryl bromides, chlorides or sulfonates with arylzinc reagents.
It can be used for the catalytic asymmetric hydrophosphonylation of enones in the presence of a dinuclear zinc complex to form γ-oxo-phosphonates.
DEP can undergo Michael addition to α,β-unsaturated malonates to form β-phosphonomalonates in the presence of recyclable nano γ-ferric oxide-pyridine based catalyst.