F9108
5-氟吲哚
98%
别名:
NSC 88613
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关于此项目
经验公式（希尔记法）:
C8H6FN
化学文摘社编号:
分子量:
135.14
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
206-917-4
Beilstein/REAXYS Number:
112350
MDL number:
产品名称
5-氟吲哚, 98%
InChI key
ODFFPRGJZRXNHZ-UHFFFAOYSA-N
InChI
1S/C8H6FN/c9-7-1-2-8-6(5-7)3-4-10-8/h1-5,10H
SMILES string
Fc1ccc2[nH]ccc2c1
assay
98%
mp
45-48 °C (lit.)
Quality Level
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Application
- 用于制备 5-HT6 受体配体
- 作为反应物，用于制备色氨酸双加氧酶抑制剂吡啶基-乙烯基-吲哚（一种潜在的抗癌免疫调节剂）
- 用于制备抗肿瘤药物的反应物
- 用于制备抗菌剂的反应物
- 用于制备免疫抑制剂的反应物
- 用于制备钠依赖性葡萄糖协同转运蛋白 2 (SGLT2) 抑制剂的反应物，用于治疗糖尿病高血糖症
- 用于制备髓过氧化物酶抑制剂的反应物
- 用于制备强效选择性 5-羟色胺再摄取抑制剂的反应物
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
230.0 °F - closed cup
flash_point_c
110 °C - closed cup
ppe
dust mask type N95 (US), Eyeshields, Gloves
A L Palombella et al.
Plant physiology, 117(2), 455-464 (1998-06-25)
We report the isolation of a Chlamydomonas reinhardtii cDNA that encodes the beta-subunit of tryptophan synthase (TSB). This cDNA was cloned by functional complementation of a trp-operon-deleted strain of Escherichia coli. Hybridization analysis indicated that the gene exists in a
Nicholas A Magnus et al.
Organic letters, 12(16), 3700-3703 (2010-08-14)
A practical synthesis of the glycogen synthase kinase-3 (GSK3) inhibitor bisarylmaleimide 1 has been accomplished employing Pictet-Spengler methodology to access the indole 7-position in preparing the benzodiazepine tricyclic fragment. A seven-step linear sequence that starts with commercially available 5-fluoroindole 7
Steffen P Graether et al.
Journal of magnetic resonance (San Diego, Calif. : 1997), 178(1), 65-71 (2005-10-04)
We show that it is feasible to use a minicoil for solid-state 19F 1H NMR experiments that has short pulse widths, good RF homogeneity, and excellent signal-to-noise for small samples while using low power amplifiers typical to liquid-state NMR. The
Peter B Crowley et al.
Chemical communications (Cambridge, England), 48(86), 10681-10683 (2012-09-25)
Fluorine-containing amino acids are valuable probes for the biophysical characterization of proteins. Current methods for (19)F-labeled protein production involve time-consuming genetic manipulation, compromised expression systems and expensive reagents. We show that Escherichia coli BL21, the workhorse of protein production, can
A J Barczak et al.
Genetics, 140(1), 303-313 (1995-05-01)
A study of the biochemical genetics of the Arabidopsis thaliana tryptophan synthase beta subunit was initiated by characterization of mutants resistant to the inhibitor 5-fluoroindole. Thirteen recessive mutations were recovered that are allelic to trp2-1, a mutation in the more
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