G10105
18β-甘草次酸
97%
别名:
乌拉尔酸, 亚葡萄糖酸, 甘草次酸
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关于此项目
经验公式（希尔记法）:
C30H46O4
化学文摘社编号:
分子量:
470.68
UNSPSC Code:
12352115
NACRES:
NA.22
PubChem Substance ID:
EC Number:
207-444-6
Beilstein/REAXYS Number:
2229654
MDL number:
Assay:
97%
InChI key
MPDGHEJMBKOTSU-YKLVYJNSSA-N
InChI
1S/C30H46O4/c1-25(2)21-8-11-30(7)23(28(21,5)10-9-22(25)32)20(31)16-18-19-17-27(4,24(33)34)13-12-26(19,3)14-15-29(18,30)6/h16,19,21-23,32H,8-15,17H2,1-7H3,(H,33,34)/t19-,21-,22-,23+,26+,27-,28-,29+,30+/m0/s1
SMILES string
CC1(C)[C@@H](O)CC[C@@]2(C)[C@H]1CC[C@]3(C)[C@@H]2C(=O)C=C4[C@@H]5C[C@](C)(CC[C@]5(C)CC[C@@]34C)C(O)=O
assay
97%
optical activity
[α]22/D +170.0°, c = 1 in chloroform
mp
292-295 °C (lit.)
Quality Level
Gene Information
human ... HSD11B1(3290), HSD11B2(3291)
rat ... Hsd11b1(25116), Hsd11b2(25117)
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General description
18 & # 946；甘草次酸是在光果甘草甘草根中发现的五环三萜类化合物。它是甘草甜素和甘草酸的主要代谢产物。
Application
该产品可用作制备18 & # 946；-甘草次酸衍生物，这种化合物显示抗炎和抗氧化特性。
存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Christian Stanetty et al.
Bioorganic & medicinal chemistry, 18(21), 7522-7541 (2010-09-21)
Glycyrrhetinic acid, the metabolite of the natural product glycyrrhizin, is a well known nonselective inhibitor of 11β-hydroxysteroid dehydrogenase (11β-HSD) type 1 and type 2. Whereas inhibition of 11β-HSD1 is currently under consideration for treatment of metabolic diseases, such as obesity
Igor Beseda et al.
Bioorganic & medicinal chemistry, 18(1), 433-454 (2009-11-17)
The effect of glycyrrhetinic acid (GA) and GA-derivatives towards 11beta-hydroxysteroid dehydrogenase (11beta-HSD) was investigated. Novel compounds with modifications at positions C-3, C-11 and C-29 of the GA skeleton were prepared. Single crystal X-ray diffraction data of selected substances are reported
Rawindra Gaware et al.
Bioorganic & medicinal chemistry, 19(6), 1866-1880 (2011-03-08)
Glycyrrhetinic acid, the metabolite of the natural product glycyrrhizin, is a well known nonselective inhibitor of 11β-hydroxysteroid dehydrogenase (11β-HSD) type 1 and type 2. Whereas inhibition of 11β-HSD1 is currently under consideration for treatment of metabolic diseases, such as obesity
A robust screening method for dietary agents that activate tumour-suppressor microRNAs.
Hagiwara K, et al.
Scientific Reports, 5 (2015)
Gaëlle Le Bras et al.
Journal of medicinal chemistry, 50(24), 6189-6200 (2007-11-06)
Selective hsp90 inhibitors simultaneously destabilize and deplete key signaling proteins involved in cell proliferation and survival, angiogenesis, and metastasis. Investigation of novobiocin analogues lacking the noviose moiety as novel inhibitors of hsp90 was carried out. A novel series of 3-aminocoumarin
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