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Merck
CN

G2137

甘草酸 铵盐 来源于甘草根(甘草)

≥70% (HPLC)

别名:

3-O-(2-O-β-D-Glucopyranuronosyl-α-D-glucopyranuronosyl)-18β-glycyrrhetinic acid 铵盐, 甘草甜

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关于此项目

线性分子式:
C42H62O16 · NH3
化学文摘社编号:
分子量:
839.96
UNSPSC Code:
12352005
NACRES:
NA.22
PubChem Substance ID:
EC Number:
258-887-7
Beilstein/REAXYS Number:
3897076
MDL number:
Assay:
≥70% (HPLC)
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Quality Level

assay

≥70% (HPLC)

storage temp.

2-8°C

SMILES string

N.CC1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]3(C)[C@@H]2C(=O)C=C4[C@@H]5C[C@](C)(CC[C@]5(C)CC[C@@]34C)C(O)=O)O[C@H]6O[C@@H]([C@@H](O)[C@H](O)[C@H]6O[C@@H]7O[C@@H]([C@@H](O)[C@H](O)[C@H]7O)C(O)=O)C(O)=O

InChI

1S/C42H62O16.H3N/c1-37(2)21-8-11-42(7)31(20(43)16-18-19-17-39(4,36(53)54)13-12-38(19,3)14-15-41(18,42)6)40(21,5)10-9-22(37)55-35-30(26(47)25(46)29(57-35)33(51)52)58-34-27(48)23(44)24(45)28(56-34)32(49)50;/h16,19,21-31,34-35,44-48H,8-15,17H2,1-7H3,(H,49,50)(H,51,52)(H,53,54);1H3/t19-,21-,22-,23-,24-,25-,26-,27+,28-,29-,30+,31+,34-,35-,38+,39-,40-,41+,42+;/m0./s1

InChI key

ILRKKHJEINIICQ-OOFFSTKBSA-N

General description

甘草酸(GA)是 11β-羟基类固醇脱氢酶(11β-HSD)的非选择性抑制剂,其介导活化和非活化糖皮质激素的相互转化。GA 还对高迁移率族蛋白 1(HMGB1)的细胞因子活性的具有抑制作用。

Application

该产品已被用作甘草酸(GA)的来源,用于研究其对用高脂肪/高蔗糖(HF/HS)饮食喂养的大鼠的葡萄糖耐受不良和胰岛素抵抗的影响。

Biochem/physiol Actions

甘草属(甘草)甜根中的生物活性组分。抗病毒。


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pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Eye Irrit. 2

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Ashraf M Morgan et al.
Environmental science and pollution research international, 26(34), 34924-34930 (2019-10-30)
Atrazine (ATR) is a common herbicide used worldwide. It is a potent endocrine disruptor that causes hormonal imbalance. We investigated the modulatory role predisposed by glycyrrhizic acid (GA) against the hazardous effects caused by the ATR in the rabbit spleen.
Novel inhibitory effects of Glycyrrhizic Acid on the accumulation of advanced glycation end product and its receptor expression.
Cheng HS, et al.
Natural products and bioprospecting, 4(6), 325-333 (2014)
High-mobility group box-1 was released actively and involved in LPS induced depressive-like behavior.
Wu TY, et al.
Journal of Psychiatric Research, 64, 99-106 (2015)



全球贸易项目编号

货号GTIN
G2137-25G04061833628676
G2137-100G04061833628669